Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s00249-018-1288-0 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Cilia-Inspired Bionic Tactile E-Skin: Structure, Fabrication and Applications.
Sensors (Basel)
December 2024
In Situ Devices Center, School of Integrated Circuits, East China Normal University, Shanghai 200241, China.
The rapid advancement of tactile electronic skin (E-skin) has highlighted the effectiveness of incorporating bionic, force-sensitive microstructures in order to enhance sensing performance. Among these, cilia-like microstructures with high aspect ratios, whose inspiration is mammalian hair and the lateral line system of fish, have attracted significant attention for their unique ability to enable E-skin to detect weak signals, even in extreme conditions. Herein, this review critically examines recent progress in the development of cilia-inspired bionic tactile E-skin, with a focus on columnar, conical and filiform microstructures, as well as their fabrication strategies, including template-based and template-free methods.
View Article and Find Full Text PDFComputational Mutagenesis of GPx7 and GPx8: Structural and Stability Insights into Rare Genetic and Somatic Missense Mutations and Their Implications for Cancer Development.
Cancers (Basel)
December 2024
Department of Biology, Howard University, Washington, DC 20059, USA.
Somatic and genetic mutations in glutathione peroxidases (GPxs), including GPx7 and GPx8, have been linked to intellectual disability, microcephaly, and various tumors. GPx7 and GPx8 evolved the latest among the GPx enzymes and are present in the endoplasmic reticulum. Although lacking a glutathione binding domain, GPx7 and GPx8 possess peroxidase activity that helps the body respond to cellular stress.
View Article and Find Full Text PDFA Role of Inflammation in Charcot-Marie-Tooth Disorders-In a Perspective of Treatment?
Int J Mol Sci
December 2024
Neuromuscular Unit, Mossakowski Medical Research Institute Polish Academy of Sciences, 02-106 Warsaw, Poland.
Despite the fact that there are published case reports and model work providing evidence of inflammation in Charcot-Marie-Tooth disorders (CMTs), in clinical practice, CMT and inflammatory neuropathies are always classified as two separate groups of disorders. This sharp separation of chronic neuropathies into two groups has serious clinical implications. As a consequence, the patients harboring CMT mutations are practically excluded from pharmacological anti-inflammatory treatments.
View Article and Find Full Text PDFStudy on SHP2 Conformational Transition and Structural Characterization of Its High-Potency Allosteric Inhibitors by Molecular Dynamics Simulations Combined with Machine Learning.
Molecules
December 2024
School of Chemical Sciences, University of Chinese Academy of Sciences, No. 19A, Yuquan Road, Beijing 100049, China.
The src-homology 2 domain-containing phosphatase 2 (SHP2) is a human cytoplasmic protein tyrosine phosphatase that plays a crucial role in cellular signal transduction. Aberrant activation and mutations of SHP2 are associated with tumor growth and immune suppression, thus making it a potential target for cancer therapy. Initially, researchers sought to develop inhibitors targeting SHP2's catalytic site (protein tyrosine phosphatase domain, PTP).
View Article and Find Full Text PDFSalivary proteomics and metaproteomics identifies distinct molecular and taxonomic signatures of type-2 diabetes.
Microbiome
January 2025
Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Blegdamsvej 3B, Copenhagen, 2200, Denmark.
Background: Saliva is a protein-rich body fluid for noninvasive discovery of biomolecules, containing both human and microbial components, associated with various chronic diseases. Type-2 diabetes (T2D) imposes a significant health and socio-economic burden. Prior research on T2D salivary microbiome utilized methods such as metagenomics, metatranscriptomics, 16S rRNA sequencing, and low-throughput proteomics.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!