A metal-free site-specific C2-hydroxyalkylation of chromones through the Minisci-type reaction using simple alcohols was developed. This transformation proceeds via radical sp C-H activation and subsequent conjugate addition, generating a series of C2-hydroxyalkylated chromanones in moderate to good yields. Besides, ethers were also compatible in this Minisci reaction, leading to corresponding C2 ether-substituted chromanones.
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| http://dx.doi.org/10.1039/c8ob00392k | DOI Listing |
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