Potential hypoglycemic effect of acetophenones from the root bark of .

Three new acetophenones, named cynwilforones A-C (-), together with cynandione A () were isolated from the root bark of (Maxim.) Hemsl. Their structures were deduced based on spectroscopic analysis and chemical methods. Compounds and exhibited potential hypoglycemic effects through inhibition of hepatic gluconeogenesis by down-regulating the expression of phosphoenolpyruvate carboxykinase and glucose-6-phosphatase. This is the first report that acetophenones from the root bark of possesses potential hypoglycemic activity .