The present work studies the microstructure and mechanical performance of tricalcium phosphate (TCP) based cermet toughened by iron particles. A novelty arises by the employment of spark plasma sintering for fabrication of the cermet. Results showed partial transformation of initial alpha TCP matrix to beta phase and the absence of oxidation of iron particles, as well as a lack of chemical reaction between TCP and iron components during sintering. The values of compressive and tensile strength of TCP/Fe cermet were 3.2 and 2.5 times, respectively, greater than those of monolithic TCP. Fracture analysis revealed the simultaneous action of crack-bridging and crack-deflection microstructural toughening mechanisms under compression. In contrast, under tension the reinforcing mechanism was only crack-bridging, being the reason for smaller increment of strength. Elastic properties of the cermet better matched values reported for human cortical bone. Thereby the new TCP/Fe cermet has potential for eventual use as a material for bone fractures fixation under load-bearing conditions.
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http://dx.doi.org/10.1016/j.jmbbm.2018.02.016 | DOI Listing |
Mater Today Bio
February 2025
Spine & Spinal Cord Institute, Department of Neurosurgery, College of Medicine, Yonsei University, Seoul, 03722, Republic of Korea.
Spinal fusion surgery remains a significant challenge due to limitations in current bone graft materials, particularly in terms of bioactivity, integration, and safety. This study presents an innovative approach using an injectable hydroxyapatite/β-tricalcium phosphate (HA/β-TCP) hydrogel combined with stromal vascular fraction (SVF) and low-dose recombinant human BMP-2 (rhBMP-2) to enhance osteodifferentiation and angiogenesis. Through a series of in vitro studies and preclinical models involving rats and minipigs, we demonstrated that the hydrogel system enables the sustained release of rhBMP-2, resulting in significantly improved bone density and integration, alongside reduced inflammatory responses.
View Article and Find Full Text PDFArtificial bone, primarily composed of calcium carbonate, demonstrates a higher resorption rate than calcium phosphate-based counterparts, suggesting potential for early bone replacement. Animal experiments using porous calcium carbonate ceramics have demonstrated bone formation superior to commercially available artificial bone after short-term implantation. Long-term implantation has yielded suboptimal results owing to resorption of both newly formed bone and implantation material.
View Article and Find Full Text PDFJ Prosthodont Res
January 2025
Department of Orthodontics, Osaka Dental University, Hirakata, Japan.
Purpose: To perform vertical bone augmentation on rat parietal bone by coating the inner surface of dense polytetrafluoroethylene (d-PTFE) domes with hydroxyapatite (HA) using Erbium Yttrium Aluminum Garnet (Er:YAG) pulsed laser deposition in a rat model.
Methods: The d-PTFE plate surface, α-tricalcium phosphate (α-TCP) coating, and HA coating were measured using scanning electron microscopy and X-ray diffraction to confirm the replacement of α-TCP with HA via high-pressure steam sterilization. The dome was glued to the center of the rat parietal bone and closed with periosteal and epithelial sutures.
Cureus
December 2024
Orthopedics and Traumatology, Unidade Local de Saúde da Cova da Beira, Covilhã, PRT.
3D Print Addit Manuf
October 2024
New Technologies Research Center, Amirkabir University of Technology, Tehran, Iran.
Robocasting calcium phosphate compounds as a novel approach to creating customized structures with interconnected pores not only overcomes the limitations of traditional fabrication methods of calcium phosphate substitutes but also boosts the potential for bone tissue regeneration. The ink development is a key step in 3D printing. In this study, different inks consisting of magnesium- and sodium-doped carbonated hydroxyapatite, β-tricalcium phosphate, and Pluronic F-127 were prepared to design biomimetic bone scaffolds.
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