AI Article Synopsis
- The study investigates how resident microbes, or microbiota, influence the development of secretory cells in zebrafish intestines, focusing on their effect on Notch signaling.* -
- Researchers found that microbiota affects Notch signaling through the Myd88-dependent innate immune pathway, leading to the promotion of secretory cell development.* -
- These findings link microbiota activity to important biological processes, suggesting that disruptions in this relationship can contribute to chronic inflammation and cancer.*
Article Abstract
Resident microbes promote many aspects of host development, although the mechanisms by which microbiota influence host tissues remain unclear. We showed previously that the microbiota is required for allocation of appropriate numbers of secretory cells in the zebrafish intestinal epithelium. Because Notch signaling is crucial for secretory fate determination, we conducted epistasis experiments to establish whether the microbiota modulates host Notch signaling. We also investigated whether innate immune signaling transduces microbiota cues via the Myd88 adaptor protein. We provide the first evidence that microbiota-induced, Myd88-dependent signaling inhibits host Notch signaling in the intestinal epithelium, thereby promoting secretory cell fate determination. These results connect microbiota activity via innate immune signaling to the Notch pathway, which also plays crucial roles in intestinal homeostasis throughout life and when impaired can result in chronic inflammation and cancer.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869004 | PMC |
| http://dx.doi.org/10.1242/dev.155317 | DOI Listing |
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