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Haploid-Phased Chromosomal Telomere-to-Telomere Genome Assembly of Medicinal Plant Uncaria rhynchophylla Dissects Genetic Controls on the Biosynthesis of Bioactive Alkaloids.
Plant Cell Environ
November 2024
Key Laboratory of Plant Resources Conservation and Germplasm Innovation in Mountainous Region (Ministry of Education), Institute of Agro-bioengineering, College of Life Sciences, Guizhou University, Guiyang, China.
Natural indole alkaloids provide important medicinal resources and defences to environmental stresses. The Uncaria genus is a recorded traditional medicinal woody plant with high alkaloids. Genomic insights into alkaloid variation remain elusive.
View Article and Find Full Text PDFElusive Unilateral Pleural Effusion: Keys to Clinching the Diagnosis.
Cureus
September 2024
Pulmonology and Critical Care, Baylor Scott and White Medical Center, Temple, USA.
Unilateral pleural effusions may sometimes be difficult to diagnose. The cause may vary widely, including congestive heart failure, chronic liver and kidney disease, various drugs, and underlying undiagnosed disorders of the lung and pleura. With advancements in chest imaging, new biomarkers, and less invasive methods for obtaining tissue samples, it may be possible to identify the cause of the unilateral pleural effusions whose etiology is unclear.
View Article and Find Full Text PDFUncovering structural themes across cilia microtubule inner proteins with implications for human cilia function.
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The Danish Cancer Society Research Center, Danish Cancer Institute, Strandboulevarden 49, 2100, Copenhagen, Denmark.
Centrosomes and cilia are microtubule-based superstructures vital for cell division, signaling, and motility. The once thought hollow lumen of their microtubule core structures was recently found to hold a rich meshwork of microtubule inner proteins (MIPs). To address the outstanding question of how distinct MIPs evolved to recognize microtubule inner surfaces, we applied computational sequence analyses, structure predictions, and experimental validation to uncover evolutionarily conserved microtubule- and MIP-binding modules named NWE, SNYG, and ELLEn, and PYG and GFG-repeat by their signature motifs.
View Article and Find Full Text PDFModafinil, an atypical CNS stimulant?
Adv Pharmacol
March 2024
Medication Development Program, NIDA-IRP, NIH, Baltimore, MD, United States. Electronic address:
Modafinil is a central nervous system stimulant approved for the treatment of narcolepsy and sleep disorders. Due to its wide range of biochemical actions, modafinil has been explored for other potential therapeutic uses. Indeed, it has shown promise as a therapy for cognitive disfunction resulting from neurologic disorders like ADHD, and as a smart drug in non-medical settings.
View Article and Find Full Text PDFEmergence of allostery through reorganization of protein residue network architecture.
J Chem Phys
February 2023
Fischell Department of Bioengineering, University of Maryland, College Park, Maryland 20742, USA.
Despite more than a century of study, consensus on the molecular basis of allostery remains elusive. A comparison of allosteric and non-allosteric members of a protein family can shed light on this important regulatory mechanism, and the bacterial biotin protein ligases, which catalyze post-translational biotin addition, provide an ideal system for such comparison. While the Class I bacterial ligases only function as enzymes, the bifunctional Class II ligases use the same structural architecture for an additional transcription repression function.
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