AI Article Synopsis
- The study aims to assess the link between antibiotic use and neurodevelopmental outcomes in extremely low gestational age infants who don’t have confirmed infections like sepsis or NEC.
- Researchers analyzed data from 1,373 infants born before 29 weeks gestation, comparing outcomes based on different levels of antibiotic utilization.
- The findings show that infants in the highest antibiotic use group had significantly higher odds of death and serious neurodevelopmental impairment compared to those in the lowest usage group.
Article Abstract
Objective: The objective is to evaluate the association between antibiotic utilization and neurodevelopmental outcomes at 18 to 21 months' corrected age among extremely low gestational age neonates without culture-proven sepsis or necrotizing enterocolitis (NEC).
Study Design: We conducted a retrospective cohort study of infants born between April 2009 and September 2011 at <29 weeks' gestation and admitted to the neonatal intensive care units contributing data to the Canadian Neonatal Network. Multivariable analysis was performed to examine the primary composite outcome of death or significant neurodevelopmental impairment (sNDI) in infants with various antibiotic utilization rates (AURs).
Result: There were 1,373 infants who fulfilled our inclusion criteria. Compared with infants in the lowest AUR quartile (Q1), those in the highest quartile (Q4) had higher odds of death or sNDI (adjusted odds ratio [AOR] = 7.44; 95% confidence interval [CI]: 4.55, 12.2) and death (AOR = 39.3; 95% CI: 16.1, 95.9).
Conclusion: Our results indicate an association between high AUR and a composite outcome of death or adverse neurodevelopmental outcomes at 18 to 21 months' corrected age.
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| http://dx.doi.org/10.1055/s-0038-1632390 | DOI Listing |
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