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http://dx.doi.org/10.2337/dc18-0011 | DOI Listing |
Nat Commun
March 2024
Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK.
Under pressure from neutralising antibodies induced by vaccination or infection the SARS-CoV-2 spike gene has become a hotspot for evolutionary change, leading to the failure of all mAbs developed for clinical use. Most potent antibodies bind to the receptor binding domain which has become heavily mutated. Here we study responses to a conserved epitope in sub-domain-1 (SD1) of spike which have become more prominent because of mutational escape from antibodies directed to the receptor binding domain.
View Article and Find Full Text PDFAnimal
April 2024
Department of Large Animal and Wildlife Clinical Science, Faculty of Veterinary Medicine, Kasetsart University, Kampeang Sean Campus, Nakorn Pathom 73140, Thailand; Thailand Equestrian Federation, Sports Authority of Thailand, Bangkok 10330, Thailand. Electronic address:
Cooling down is essential for horse recovery before veterinary inspection during an endurance ride. As salt potentially decreases water temperature, we tested whether adding salt to the water used to cool horses could aid their recovery. Twelve healthy Arabian horses participating in a novice endurance ride were divided evenly into two groups.
View Article and Find Full Text PDFSci Rep
March 2024
Universidade de Brasília, Faculdade de Educação Física, Programa de Pós-graduação em Educação Física, Laboratório de Fisiologia do Exercício, Brasília, DF, 70910-900, Brazil.
The present study sought to expand upon prior investigations of the relationship between post-exercise heart rate recovery (HRR) and cardiovagal resting-reactivity modulation. HRR from 1st to 5th min after maximal exercise test was correlated with a cardiovagal index of heart rate variability (SD1) at resting (supine and orthostatic positions) and its reactivity after the orthostatic stress test in 34 healthy women. Statistical analysis employed non-parametric tests with a p-value set at 5%.
View Article and Find Full Text PDFPhysiol Rep
March 2024
School of Biomedical Sciences, Faculty of Health, University of Plymouth, Plymouth, UK.
Hypoxia is mainly caused by cardiopulmonary disease or high-altitude exposure. We used a driving simulator to investigate whether breathing hypoxic gas influences driving behaviors in healthy subjects. Fifty-two healthy subjects were recruited in this study, approved by the Science and Engineering Ethical Committee.
View Article and Find Full Text PDFInt Arch Occup Environ Health
May 2024
Department of Neurology, Wuhan No.1 Hospital, Wuhan, 430022, People's Republic of China.
Purpose: Whether chronotype affects the health outcomes of night shift work populations is unknown. This study aimed to assess the influence of different chronotypes in the rotating night shift population on sleep status, mood, blood pressure (BP), and heart rate variability (HRV), as well as the circadian rhythm of BP and HRV.
Methods: A total of 208 rotating night shift workers were included.
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