AI Article Synopsis
- Research indicates that Mycobacterium tuberculosis can persist in human bone marrow stem cells, potentially serving as a reservoir during latent tuberculosis.* -
- In experiments using mice, it was shown that transferring infected bone marrow cells to healthy mice resulted in the spread of tuberculosis, primarily when both groups lacked a specific enzyme (inducible nitric oxide synthase) that helps kill bacteria.* -
- The study suggests that if the body's ability to produce nitric oxide is impaired, bone marrow stem and progenitor cells with M. tuberculosis can contribute to the progression of the disease.*
Article Abstract
Persistence of Mycobacterium tuberculosis within human bone marrow stem cells has been identified as a potential bacterial niche during latent tuberculosis. Using a murine model of tuberculosis, we show here that bone marrow stem and progenitor cells containing M. tuberculosis propagated tuberculosis when transferred to naive mice, given that both transferred cells and recipient mice were unable to express inducible nitric oxide synthase, which mediates killing of intracellular bacteria via nitric oxide. Our findings suggest that bone marrow stem and progenitor cells containing M. tuberculosis propagate hallmarks of disease if nitric oxide-mediated killing of bacteria is defective.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5913604 | PMC |
| http://dx.doi.org/10.1093/infdis/jiy041 | DOI Listing |
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