: To compare genetic testing for microbes in infectious endophthalmitis or uveitis to culture.: This was a retrospective, single-center case series that enrolled patients with clinically suspected endophthalmitis or uveitis of unknown etiology. Aqueous humor or vitreous was collected and sent for routine cultures and genetic testing.: In total, 46 patients were enrolled. Genetic testing was positive in 32/46 (70%) cases and culture 6/46 cases (13%). Five of 16 uveitis cases had a final clinical diagnosis of infectious uveitis, and polymerase chain reaction (PCR) was positive in 4/5 cases (80%), versus 0% for culture. In uveitis cases, PCR was 80% sensitive and 82% specific, and culture had 0% sensitivity. The overall sensitivity and specificity of PCR for all cases were 85% and 67%, respectively, compared with 17% and 100% for culture.: Genetic assays are inexpensive ($25/case) and more sensitive than culture for identifying intraocular pathogens in endophthalmitis and uveitis.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1080/09273948.2018.1431291 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Unilateral Exudative Retinal Detachment and Uveitis Accompanied by a Large Subretinal Deposit on the Macula Secondary to Bartonella Henselae Infection.
Diagnostics (Basel)
December 2024
Beijing Children's Hospital, Capital Medical University, Beijing 100070, China.
Bartonella henselae is a Gram-negative bacillus, mainly parasitizing on cats. When a child is scratched by a cat, they may present with the disease symptoms including regional lymphadenopathy, malaise, fever, and splenomegaly, which is known as cat-scratch disease (CSD). Ocular manifestations occur in 5-10% of patients with CSD.
View Article and Find Full Text PDFAflibercept high-dose (8mg) related intraocular inflammation (IOI) - a case series.
BMC Ophthalmol
December 2024
Vista Augenklinik Binningen, Hauptstrasse 55, Binningen, 4102, Switzerland.
Background: Monitoring for potential inflammatory events following intravitreal anti-vascular endothelial factor (VEGF) injection is crucial with the use of new agents such as aflibercept 8 mg. Despite a safety profile comparable to aflibercept 2 mg in pivotal and phase 3 studies, reporting such cases in clinical practice helps evaluate potential risk of these agents.
Case Presentation: In this case series, a cluster of 8 patients manifesting acute intraocular inflammation (IOI) after intravitreal aflibercept 8 mg injection at three different centers are described.
State-of-the-Art Review: Ocular Infections.
Clin Infect Dis
November 2024
Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.
Collaborations between ophthalmologists and infectious disease specialists are critical for optimizing care of many patients with eye infections. We review challenges in common and uncommon eye infections to promote better understanding of these infections and prioritize areas for further research.
View Article and Find Full Text PDFBilateral Endogenous Endophthalmitis As a First Presentation of Endocarditis.
J Vitreoretin Dis
September 2024
Jones Eye Institute, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
To present a case of bilateral endogenous endophthalmitis as the first presentation of endocarditis. A single case was evaluated. A 64-year-old Black woman presented with rapidly progressive bilateral vision loss.
View Article and Find Full Text PDFDeciphering infectious uveitis etiology: Immune cell profiling in keratic precipitates using in vivo confocal microscopy.
Heliyon
November 2024
Department of Ophthalmology, the Second Xiangya Hospital, Central South University, China.
Purpose: To elucidate the etiology of infectious uveitis through the comprehensive analysis of keratic precipitates (KPs) using in vivo confocal microscopy (IVCM).
Design: Cross-sectional, observational case series.
Methods: This single-center, cross-sectional study was conducted at a tertiary care eye hospital from January 2021 to October 2023.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!