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Estimated Brain Tissue Response Following Impacts Associated With and Without Diagnosed Concussion. | LitMetric

AI Article Synopsis

  • Kinematic measurements of head impacts can indicate sports concussions but lack specificity due to their focus on impact input rather than regional brain deformation.
  • This study analyzed head impact data from high school and collegiate football players, using finite element head models to simulate both concussed and non-concussed impacts.
  • While various intracranial response measures showed sensitivity to diagnosed concussions, there was significant variability among athletes, and estimates of concussion risk did not surpass those based solely on impact kinematics.

Article Abstract

Kinematic measurements of head impacts are sensitive to sports concussion, but not highly specific. One potential reason is these measures reflect input conditions only and may have varying degrees of correlation to regional brain tissue deformation. In this study, previously reported head impact data recorded in the field from high school and collegiate football players were analyzed using two finite element head models (FEHM). Forty-five impacts associated with immediately diagnosed concussion were simulated along with 532 control impacts without identified concussion obtained from the same players. For each simulation, intracranial response measures (max principal strain, strain rate, von Mises stress, and pressure) were obtained for the whole brain and within four regions of interest (ROI; cerebrum, cerebellum, brain stem, corpus callosum). All response measures were sensitive to diagnosed concussion; however, large inter-athlete variability was observed and sensitivity strength depended on measure, ROI, and FEHM. Interestingly, peak linear acceleration was more sensitive to diagnosed concussion than all intracranial response measures except pressure. These findings suggest FEHM may provide unique and potentially important information on brain injury mechanisms, but estimations of concussion risk based on individual intracranial response measures evaluated in this study did not improve upon those derived from input kinematics alone.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5935583PMC
http://dx.doi.org/10.1007/s10439-018-1999-5DOI Listing

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