Serum S100 Proteins as a Marker of Disease Activity in Large Vessel Vasculitis.

Background/objectives: Serum S100A8/S100A9 and S100A12 levels have been shown to be elevated in giant cell arteritis (GCA). This study aimed to determine if levels of serum S100 proteins perform as markers in a comparable fashion to standard markers of disease activity in large-vessel vasculitis.

Methods: Serum samples were obtained from the Vasculitis Clinical Research Consortium (VCRC) Longitudinal Prospective Cohort Study of GCA and Takayasu’s arteritis (TAK). A mixed effects model compared S100 proteins during active and inactive disease states. Receiver operating characteristic curves compared models using S100 proteins to models using ESR and CRP.

Results: There were 106 samples (50 during active disease) from patients with GCA and 32 samples (16 during active disease) from patients with TAK. In GCA, S100A8/S100A9 and S100A12 were significantly elevated during active disease (1445.6 ng/mL vs. 1095.7 ng/mL, p = 0.003;163.2 ng/mL vs. 116.6ng/mL, p=0.016, respectively). There were weak correlations between levels of S100 proteins and ESR or CRP. A model including S100A8/S100A9, S100A12, ESR, and CRP was a better indicator of disease activity compared to ESR and CRP together. In TAK, there were no significant differences between active and inactive disease for either the S100 proteins or ESR/CRP.

Conclusions: Serum levels of S100A8/S100A9 and S100A12 are elevated during active disease and perform comparably to ESR and CRP as measures of disease activity in giant cell arteritis.