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Improved Hematology Analysis Based on Microfluidic Impedance Spectroscopy: Erythrocyte Orientation and Anisotropic Dielectric Properties of Flowing Blood.
Anal Chem
January 2025
School of Mechanical and Robotics Engineering, Gwangju Institute of Science and Technology (GIST), Gwangju 61005, Republic of Korea.
Electrochemical impedance spectroscopy has great potential for laboratory blood tests. The overall aim of this study is to develop a microfluidic sensor for determining the physical properties and hematological parameters of blood based on its dielectric spectra. Impedance was measured in flowing blood to prevent aggregation and sedimentation at frequencies between 40 Hz and 110 MHz.
View Article and Find Full Text PDFImplementation of the I-DECIDED tool for PIVC assessment and decision making: discussion paper.
Br J Nurs
January 2025
Postgraduate Program in Nursing, Nursing Department, Health Sciences Centre, Universidade Federal de Santa Catarina, Florianopolis, Brazil.
Highlights: PIVCs often cause pain, irritation, or infection. Regular and careful catheter checks can decrease complications and improve patient outcomes. Implementation of the I-DECIDED® tool led to fewer idle catheters and complications.
View Article and Find Full Text PDFBackground: The burden of hospital-acquired infections (HAIs) equates to 3.5 million cases, resulting in more than 90 000 deaths and 2.5 million disability-adjusted life years (DALYs) across Europe.
View Article and Find Full Text PDFA multimodal approach to reduce the incidence of peripheral venous cannula bacteraemias and improve patient safety.
Br J Nurs
January 2025
Audit and Surveillance Specialist Nurse, Infection Prevention and Control, Royal Devon University Healthcare NHS Foundation Trust.
Background: Incidence of peripheral venous cannula (PVC) bacteraemia have been rising in a trust in the south-west of England, with a 267% increase noted over the 2022/23 financial year compared with the previous year.
Aim: To use a multimodal approach to reduce the incidence of PVC bacteraemia and improve patient safety.
Methods: The initiative consisted of an educational poster highlighting the severity of infection associated with PVCs alongside key prevention messages rooted in Trust policy.
Telomerase in cancer- ongoing quest and future discoveries.
Mol Biol Rep
January 2025
Department of Integrative Biology, School of Bio-Sciences and Technology, Vellore Institute of Technology, Vellore, Tamil Nadu, 632014, India.
Telomerase, constituted by the dynamic duo of telomerase reverse transcriptase (TERT), the catalytic entity, and an integral RNA component (TERC), is predominantly suppressed in differentiated human cells due to postnatal transcriptional repression of the TERT gene. Dysregulation of telomerase significantly contributes to cancer development via telomere-dependent and independent mechanisms. Telomerase activity is often elevated in advanced cancers, with TERT reactivation and upregulation of TERC observed in early tumorigenesis.
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