Objective: To understand the epidemic status of alveolar echinococcosis in Tibetan children in south Qinghai Province.
Methods: The imageology and serology methods were applied to investigate the epidemic status of alveolar echinococcosis of elementary school students in Yushu and Guoluo prefectures.
Results: Totally 19 629 children were investigated by the portable B ultrasound and 221 children were diagnosed as alveolar echinococcosis with the morbidity of 1.13%. Totally 9 888 were investigated by the indirect ELISA, and the positive rate of serum tests was 12.59% (190/9 888). The total morbidity of alveolar echinococcosis of children in Yushu Prefecture was 0.42% (31/7 454) and it was 1.57% (190/12 175) in Guoluo Prefecture and there was a significant difference between them ( = 53.42, ＜0.005). The sero-positive rates of children in Yushu and Guoluo were 4.26% (302/7 081) and 18.56% (1 835/9 888), respectively ( = 765.77, ＜0.005). The counties with the highest prevalence of alveolar echinococcosis in children were Dari County (4.31%, 106/2 461) and Banma County (1.92%, 26/1 351) of Guoluo Prefecture, and Chengduo County (1.11%, 18/1 612) of Yushu Prefecture. The total morbidity rates of alveolar echinococcosis of male and female children were 0.91% (91/9 954) and 1.34% (130/12 175) respectively ( = 7.35, ＜0.005). The total sero-positive rates of alveolar echinococcosis of male and female children were 12.10% (1 037/8 568) and 13.09% (1 100/8 406) respectively ( = 3.63, ＞0.05). The total morbidity of alveolar echinococcosis of children in different age groups was from 1.00% to 1.13%, and there was no significant difference among the age groups ( = 2.73, ＞0.05). The P1a type, P1b type and P2 type accounted for 67.76% (145/214), 10.75% (23/214) and 16.36% (35/ 214) respectively among the alveolar echinococcosis patients. The diameters of nidus of 87.38% (187/214) patients were less than 5 cm, and 2.80% (6/214) were more than 10 cm.
Conclusions: The epidemic status of alveolar echinococcosis of Tibetan children in south Qinghai Province is serious, but most of the patients were at early stage of the disease. The screening work of alveolar echinococcosis should be strengthened in Tibetan children, so as to perform the early diagnosis and treatment.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.16250/j.32.1374.2016235 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Targeted Theranostic Nanoprobes Assisted NIR-II Fluorescence Imaging-Guided Surgery Therapy for Alveolar Echinococcosis.
ACS Appl Mater Interfaces
January 2025
School of Public Health, Xinjiang Medical University, Urumqi 830054, China.
Alveolar echinococcosis (AE) is a serious parasitic infectious disease that is highly invasive and destructive to the liver and has a high mortality rate. However, currently, there is no effective targeted imaging and treatment method for the precise detection and therapy of AE. We proposed a new two-step targeting strategy (TSTS) for AE based on poly(lactic--glycolic acid) (PLGA).
View Article and Find Full Text PDFDetection of Echinococcus spp. and other taeniid species in lettuces and berries: Two international multicenter studies from the MEmE project.
Int J Food Microbiol
January 2025
Anses, Nancy Laboratory for Rabies and Wildlife, Malzéville, France.
Cystic and alveolar echinococcosis are severe zoonotic diseases characterized by long asymptomatic periods lasting months or years. Viable Echinococcus spp. eggs released into the environment through the feces of canids can infect humans through accidental ingestion via hand-to-mouth contact or consumption of contaminated food or water.
View Article and Find Full Text PDFThe first case of alveolar echinococcosis from southern Croatia: progressive course of the disease in an immunocompromised patient.
Germs
September 2024
MD, PhD, Infectious Diseases Department, University Hospital of Split, HR-21000 Split, Croatia, and University of Split School of Medicine, HR-21000 Split, Croatia, and University Department of Health Studies of the University of Split, HR-21000 Split, Croatia.
Introduction: Alveolar echinococcosis is one of the most pathogenic zoonoses caused by the larval forms of . It is endemic in central Europe, but from 2001 to 2018, eight European countries reported their first cases of alveolar echinococcosis. These numbers testify to unprecedented spread of the infection.
View Article and Find Full Text PDFCombined two-step vascular exclusion and modified in situ hypothermic perfusion for advanced hepatic alveolar echinococcosis with cavernous transformation of portal vein (with video).
Hepatobiliary Pancreat Dis Int
December 2024
Department of Hepatobiliary and Pancreas Surgery, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610072, China. Electronic address:
Inhibition of the MyD88 signaling pathway could upregulates Ghrelin expression to synergistically regulate hepatic -infected progression.
Front Immunol
January 2025
State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Clinical Medicine Institute, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.
Introduction: AE and whether the inhibition of the MyD88 inflammatory pathway can enhance Ghrelin expression to collaboratively modulate AE progression remains unclear.
Methods: In this study, we evaluated Ghrelin serum levels and changes in TLR4/MyD88/NF-κB pathway proteins and inflammatory factors in AE patients and mouse models at different stages of infection (-4, -8, and -12 weeks). Additionally, we administered the MyD88 inhibitor TJ-M2010-5 intraperitoneally to infected mice to evaluate alterations in inflammation and Ghrelin levels, as well as disease progression.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!