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Validating a clinically based MS-MLPA threshold through comparison with Sanger sequencing in glioblastoma patients.
Clin Epigenetics
January 2025
Center of Oncocytogenomics, Institute of Medical Biochemistry and Laboratory Diagnostics, General University Hospital and 1st Faculty of Medicine of Charles University in Prague, U Nemocnice 499/2, 128 00, Prague, Czech Republic.
Background: Glioblastoma is the commonest malignant brain tumor and has a very poor prognosis. Reduced expression of the MGMT gene (10q26.3), influenced primarily by the methylation of two differentially methylated regions (DMR1 and DMR2), is associated with a good response to temozolomide treatment.
View Article and Find Full Text PDFImpact of commercial gut health interventions on caecal metagenome and broiler performance.
Microbiome
January 2025
Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK.
Background: Maintaining gut health is a persistent and unresolved challenge in the poultry industry. Given the critical role of gut health in chicken performance and welfare, there is a pressing need to identify effective gut health intervention (GHI) strategies to ensure optimal outcomes in poultry farming. In this study, across three broiler production cycles, we compared the metagenomes and performance of broilers provided with ionophores (as the control group) against birds subjected to five different GHI combinations involving vaccination, probiotics, prebiotics, essential oils, and reduction of ionophore use.
View Article and Find Full Text PDFThe moderating effects of nurses' characteristics on the perceptions and practices of family-centered care for chronically ill children and their families in Saudi Arabia.
BMC Nurs
January 2025
Department of Psychiatric and Mental Health, and Community Health, College of Nursing, Qassim University, 51452, Buraydah, Saudi Arabia.
Background/purpose: Nurses play a vital role in providing effective family-centered care (FCC) to enhance the quality of healthcare for children with chronic illnesses and increase family satisfaction. This study aimed to investigate nurses' perceptions and practices of FCC for children with chronic illnesses, and how nursing characteristics influence this relationship.
Method: This multicenter cross-sectional study involved a convenience sample of 405 nurses, each with at least six months of experience caring for chronically ill children, infants, and toddlers in Saudi Arabia.
Critical factors influencing live birth rates in fresh embryo transfer for IVF: insights from cluster ensemble algorithms.
Sci Rep
January 2025
Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, 610075, China.
Infertility has emerged as a significant global health concern. Assisted reproductive technology (ART) assists numerous infertile couples in conceiving, yet some experience repeated, unsuccessful cycles. This study aims to identify the pivotal clinical factors influencing the success of fresh embryo transfer of in vitro fertilization (IVF).
View Article and Find Full Text PDFSpatiotemporal glacier retreat on the Tibetan Plateau since the LGM to early holocene based on compilation of moraine boulder ages.
Sci Rep
January 2025
School of Geography, Nanjing Normal University, Nanjing, 210023, Jiangsu, China.
Tibetan Plateau and its surrounding mountains (TPSM) have experienced prominent glacier retreat since the Global Last Glacial Maximum, while the detailed deglaciation process remains unclear. To investigate the spatiotemporal pattern of the glacier retreat history, we compiled 196 moraines dating from 26.5 to 10 ka based on 994 boulder Be exposure age from seven regions on the TPSM and calculated the separated component Gaussians of moraine ages.
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