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Construction of Immune Single Domain Antibodies Library for Development of Specific Nanobodies Using Phage Display Strategy.
Recent Pat Biotechnol
January 2025
Center of Excellence in Recombinant Biopharmaceutical Proteins, Biochemistry and Molecular Biology Department, Theodor Bilharz Research Institute, Giza, Egypt.
Background: poses a considerable global public health challenge. In Egypt, approximately 60% of the inhabitants in the Northern and Eastern areas of the Nile Delta are affected by this parasite, whereas the Southern region experiences a significantly lower infection rate of 6%.
Aim: Construction of an immune phage display Nbs library based on the VHH framework for selecting -specific Nbs for seeking cost-effective, sensitive, and specific diagnostic tools for rapidly detecting mansoni.
Evaluation of the recombinant protein -TSP-2 for the serological diagnosis of imported urogenital schistosomiasis and comparison with commercially available tests.
Parasitology
January 2025
Tropical Medicine Unit, Hospital Universitario Poniente, Ctra. de Almerimar 31, 04700 El Ejido, Spain.
Different agencies have emphasized the need to evaluate current serological methods for screening patients with suspected urogenital schistosomiasis. However, there is still a lack of evidence regarding the most appropriate methods for this purpose. Here we assessed the diagnostic efficacy of a newly developed serological technique that utilizes the recombinant protein -TSP-2, applied to the urine and serum of migrants suspected of having urogenital schistosomiasis.
View Article and Find Full Text PDF[Health education and health promotion during the progress towards schistosomiasis elimination Ⅰ Investigation on health education needs and available resource based on integration of community resources].
Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi
November 2024
Jiangxi Provincial Institute of Parasitic Diseases, Nanchang, Jiangxi 330096, China.
Objective: To investigate the health education needs and available resources in schistosomiasis-endemic areas based on integration of community resources, and to explore the operation pathways for health education and promotion during the stage of schistosomiasis elimination.
Methods: A community was selected from Nanji Township, Xinjian District, Nanchang City, Jiangxi Province around the Poyang Lake areas as the study site, and a questionnaire survey on health education needs for schistosomiasis control was conducted among permanent residents at ages of 20 years in the community during the period between June and July, 2022 using face-to-face interviews. In addition, the resources available for the community-based schistosomiasis control health education were investigated among workers in township-level specialized institutions, members of civil society organizations, villagers, teachers and high and primary school students through field observations, field surveys and thematic interviews.
[Spatial distribution characteristics of in different water systems in Anqing City from 2016 to 2022].
Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi
June 2024
Anqing Municipal Institute of Schistosomiasis Control, Anqing, Anhui 246001, China.
Objective: To investigate the distribution of snails in different water systems in Anqing City from 2016 to 2022, so as to provide insights into snail control in the city.
Methods: Snail survey data and distribution of water systems in snail-infested environments were collected from schistosomiasis-endemic areas of Anqing City from 2016 to 2022. The vector maps of towns and water systems in Anqing City were downloaded from National Geomatics Center of China.
[Spatio-temporal distribution characteristics of snails spread in Suzhou City of Jiangsu Province from 2016 to 2023].
Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi
November 2024
Suzhou Center for Disease Prevention and Control, Suzhou, Jiangsu 215000, China.
Objective: To investigate the snails spread and its spatio-temporal clustering characteristics in Suzhou City, Jiangsu Province from 2016 to 2023, so as to provide insights into precision control of snails in the City.
Methods: snail surveillance data in Suzhou City from 2016 to 2023 were collected, and the areas of snail spread and areas of emerging and re-emerging snail habitats were retrieved. The spatial distribution characteristics and clustering types and locations of environments with snail spread were investigated using global and local spatial auto correlation analyses with the software ArcGIS 10.
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