To elucidate the pathophysiological role of atrial natriuretic polypeptide (ANP) in the brain in hypertension, the tissue concentrations and contents of alpha-rat ANP-like immunoreactivity (alpha-rANP-Ll) in the hypothalamus and septum of 4-week or 18-week-old spontaneously hypertensive rats (SHR) were studied using a radio-immunoassay (RIA) for alpha-rANP and compared with those of age-matched Wistar-Kyoto rats (WKY). The concentration and content of alpha-rANP-Ll in these regions of both 4-week and 18-week-old SHR were significantly higher that those of WKY (P less than 0.05). High performance gel permeation chromatography coupled with the RIA showed that the gel filtration profile of alpha-rANP-Ll in SHR was essentially identical to that of WKY. Since the hypothalamus and septum are known to be critical areas for water and electrolyte balance, and blood pressure control, these results suggest that ANP plays a pathophysiological role in these brain regions of SHR.
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