Nucleophilic trifluoromethylthiolation of bromoalkynones with AgSCF: C(sp)-SCF bond formation towards ynonyl trifluoromethyl sulfides.

Org Biomol Chem

Key Laboratory of Functional Molecular Engineering of Guangdong Province, School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, China.

Published: March 2018

An AgSCF mediated nucleophilic trifluoromethylthiolation reaction for C(sp)-SCF bond formation is reported. This nucleophilic trifluoromethylthiolation reaction of bromoalkynones afforded various useful ynonyl trifluoromethyl sulfides in high yields. Interestingly, the over-addition of AgSCF is avoided in our approach.

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Source
http://dx.doi.org/10.1039/c8ob00007gDOI Listing

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