Recent progress of C-glycosylation methods in the total synthesis of natural products and pharmaceuticals.

Org Biomol Chem

Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Science, Nanyang Technological University, Singapore 637371.

Published: March 2018

AI Article Synopsis

  • C-glycosylation has significantly advanced in recent years, enhancing the stereoselectivity of chemical reactions.
  • This technique is particularly effective for creating C-glycosides and O-cyclic compounds, making it valuable for synthesizing biologically active molecules.
  • The review focuses on the various C-glycosylation methods utilized in the total synthesis of natural products and pharmaceuticals over the last decade.

Article Abstract

Chemical C-glycosylation has been well developed to improve stereoselectivity in recent years. Due to its high efficiency to build C-glycosides or O-cyclic compounds, C-glycosylation has found widespread use in the synthesis of biologically active molecules. This review highlights the C-glycosylation methods that have been practised in the total synthesis of natural products and pharmaceuticals in the past decade.

Download full-text PDF

Source
http://dx.doi.org/10.1039/c8ob00032hDOI Listing

Publication Analysis

Top Keywords

c-glycosylation methods
8
total synthesis
8
synthesis natural
8
natural products
8
products pharmaceuticals
8
progress c-glycosylation
4
methods total
4
pharmaceuticals chemical
4
chemical c-glycosylation
4
c-glycosylation well
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!