The emergence of azole-resistant has become a clinical problem in many parts of the world. Several amino acid mutations in the azole target protein Cyp51Ap contribute to this resistance, with the most concerning being the environmentally derived TR/L98H and TR/Y121F/T289A mutations. Here, we performed passive surveillance to assess a sample of the population in the United States for the presence of these mutations. We found 1.4% of those isolates to exhibit elevated MIC via broth microdilution, and five of those isolates harbored the TR/L98H mutation.
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| http://dx.doi.org/10.1128/AAC.02240-17 | DOI Listing |
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