Background: Pulmonary carcinoids (PC) are rare malignant neoplasms that cover approximately 1% of all lung cancers. PCs are classified by histological criteria as either typical (TC) or atypical (AC). Histological subtype is the most studied prognostic factor. The aim of this study was to evaluate if other tissue or clinical features are associated with patient outcomes.
Material And Methods: We retrospectively reviewed clinical records of 133 PC patients who underwent operation in the Helsinki University Hospital between 1990 and 2013. Tissue specimens were re-evaluated, processed into tissue microarray format and stained immunohistochemically with serotonin, calcitonin, adrenocorticotropic hormone (ACTH), thyroid transcription factor-1 (TTF-1) and Ki-67. Survival and risk analyses were performed.
Results: Based on histology, 75% (n = 100) of the tumors were TCs and 25% (n = 33) ACs. TCs had higher 10-year disease-specific survival (DSS) rate than ACs (99% (95% CI, 93-100%) for TCs vs. 82% (95% CI, 61-92%) for ACs). Hormonally active tumors expressing serotonin, calcitonin or ACTH were noted in 53% of the specimens but hormonal expression was not associated with DSS. TTF-1 was positive in 78% of the specimens but was not associated with DSS. Ki-67 index varied between <1% and 15%. Ki-67 ≥ 2.5% was associated with shorter DSS (p = .004). The presence of metastatic disease (p = .001), tumor size ≥30 mm (p = .021) and atypical histology (p = .011) were also associated with disease-specific mortality.
Conclusions: We conclude that PCs are uncommon tumors. When resected, the long-term survival is in general favorable. In this consecutive, single-institution cohort of patients, presence of metastatic disease, tumor size, histological subtype and Ki-67 index were associated with shorter disease-specific survival. As TC and AC have different clinical behaviors, the correct tumor classification at the time of diagnosis is a necessity.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1080/0284186X.2018.1441543 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Shared Genetics of Migraine and Gastrointestinal Disorders Implicates Underlying Neurologic Mechanisms Yet Heterogeneous Etiologies.
Neurol Genet
December 2024
From the Division of Preventive Medicine (D.I.C., Y.G., P.M.R.), Brigham and Women's Hospital and Harvard Medical School; and the Clinical and Translational Epidemiology Unit (A.T.C., K.S.) and Division of Gastroenterology (A.T.C., K.S.), Massachusetts General Hospital, and Harvard Medical School, Boston, MA.
Background And Objectives: Migraine is strongly comorbid with irritable bowel syndrome (IBS), one of several gastrointestinal (GI) conditions that are distinguished by symptomatic profiles that are partly overlapping. Potential shared mechanisms of migraine and the GI conditions were investigated by assessing shared genetics on a genome-wide basis.
Methods: Analyses leveraged genome-wide summary statistics from large-scale genetic studies for migraine, including by aura status, IBS, peptic ulcer disease (PUD), gastrointestinal reflux (GERD), functional dyspepsia (FD), diverticular disease (DD), and the immune-related inflammatory bowel disease (IBD) or its constituents, ulcerative colitis (UC) and Crohn disease (CD).
Safety of Rimegepant in Adults with Migraine and Anxiety, Depression, or Using Antidepressants: Analysis of a Multicenter, Long-Term, Open-Label Study.
Pain Ther
February 2025
Pfizer Inc, Groton, CT, USA.
Introduction: Anxiety and depression are frequently associated with migraine, and antidepressant use can complicate treatment. These analyses assessed the safety and tolerability of rimegepant in participants with migraine and anxiety and/or depression, or using selective serotonin reuptake inhibitors (SSRIs) and/or other antidepressants.
Methods: Data were from a phase II/III safety study of rimegepant for the acute treatment of migraine.
Hormones in malaria infection: influence on disease severity, host physiology, and therapeutic opportunities.
Biosci Rep
November 2024
School of Biotechnology, Kalinga Institute of Industrial Technology (Deemed University), Bhubaneswar, 751024, India.
Human malaria, caused by Plasmodium parasites, is a fatal disease that disrupts the host's physiological balance and affects the neuroendocrine system. This review explores how malaria influences and is influenced by hormones. Malaria activates the Hypothalamus-Pituitary-Adrenal axis, leading to increased cortisol, aldosterone, and epinephrine.
View Article and Find Full Text PDFSubtyping of pancreatic neuroendocrine tumors by transcription factors, hormones, histology, and patient outcome.
Pathologie (Heidelb)
November 2024
Department of Pathology, TUM School of Medicine and Health, Munich, Trogerstr. 18, 81675, Munich, Germany.
Article Synopsis
- The study investigated pancreatic neuroendocrine tumors (PanNETs) and identified five distinct subtypes based on the expression of transcription factors (TFs) and their correlation with histology, hormone production, and patient outcomes.
- Subgroups A1 and A2 showed a strong association with certain growth patterns and hormone expressions, whereas subgroup B was specifically linked to insulin production, including all insulinomas.
- The findings suggest that the different subtypes of PanNETs can be used to predict histological features, hormonal activity, and prognosis in patients, providing insights for better clinical management.
Updated Morphological and Immunohistochemical Profile of Neuroendocrine Tumors Developing in Ovarian Teratomas: A Large Series of a Rare and Heterogeneous Disease.
Int J Surg Pathol
October 2024
Department of Pathology, Hôpital Bichat, AP-HP, Paris, France.
Article Synopsis
- Ovarian neuroendocrine tumors (NETs) are rare tumors often found in mature teratomas, but there hasn’t been a recent study looking at their characteristics using new tumor markers.
- This study analyzed 34 unilateral NETs, identifying four distinct immunophenotypic profiles and determining the tumors' grade and proliferation rates with specific markers.
- The findings indicate that the most common NET type shows an intestinal phenotype, suggesting a neuroendocrine precursor in the teratoma and emphasizing that these tumors shouldn't be classified based on the surrounding teratoma components.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!