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The Transcription Factor StuA Regulates Oxidative Stress-Responsive Genes in .
Int J Mol Sci
December 2024
Department of Genetics, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto 14049-900, SP, Brazil.
Fungi can remarkably sense and adapt to various extracellular stimuli and stress conditions. Oxidative stress, which results from an imbalance between reactive oxygen species production and antioxidant defenses, leads to cellular damage and death. In , oxidative stress is managed by a complex antioxidant system, including thioredoxins, glutathione, catalases, peroxidases, and superoxide dismutase, with glutathione playing a crucial role.
View Article and Find Full Text PDFPotent Antimicrobial Azoles: Synthesis, In Vitro and In Silico Study.
Antibiotics (Basel)
November 2024
Department of Pharmacy, "G. d'Annunzio" University of Chieti-Pescara, 66100 Chieti, Italy.
: The increase in fungal infections, both systemic and invasive, is a major source of morbidity and mortality, particularly among immunocompromised people such as cancer patients and organ transplant recipients. Because of their strong therapeutic activity and excellent safety profiles, azole antifungals are currently the most extensively used systemic antifungal drugs. Antibacterial properties of various topical antifungals, such as oxiconazole, which features oxime ether functionality, were discovered, indicating an exciting prospect in antimicrobial chemotherapy.
View Article and Find Full Text PDFStrain Expressed Constitutively High Levels of Sterol 14-α Demethylase mRNA, While Transporter and mRNA Expression Was Induced After Addition of Short Chain Azoles.
J Fungi (Basel)
October 2024
Department of Dermatology, Jena University Hospital, Friedrich Schiller University, D-07747 Jena, Germany.
is an emerging pathogen causing recalcitrant skin infections and exhibiting multiple resistances to azoles and allylamines. Squalene epoxidase mutants often show association with azole resistance. RT-PCR gene expression analysis helps to elucidate the connection between ergosterol biosynthesis regulation and efflux control through the activation of multidrug resistance (MDR) and major facilitator superfamily (MFS1) transporters as well as heat shock proteins (HSP).
View Article and Find Full Text PDFAn efficient gene targeting system using Δku80 and functional analysis of Cyp51A in Trichophyton rubrum.
AMB Express
August 2024
Research Institute of Pharmaceutical Sciences, Faculty of Pharmacy, Musashino University, Tokyo, 202-8585, Japan.
Trichophyton rubrum is one of the most frequently isolated fungi in patients with dermatophytosis. Despite its clinical significance, the molecular mechanisms of drug resistance and pathogenicity of T. rubrum remain to be elucidated because of the lack of genetic tools, such as efficient gene targeting systems.
View Article and Find Full Text PDFDesign, synthesis, docking studies and bioactivity evaluation of 1,2,3-triazole eugenol derivatives.
Future Med Chem
October 2024
Universidade de Vila Velha, Departamento de Farmácia, Programa de Pós-Graduação em Ciências Farmacêuticas, Av. Comissário José Dantas de Melo, 21, Vila Velha, Espírito Santo State, 29102-770, Brazil.
The design, synthesis, docking studies and evaluation of the antifungal and cytotoxic properties of eugenol (EUG) containing 1,2,3-triazole derivatives are reported. Most of the derivatives have not been reported. The EUG derivatives were synthesized, molecular docked and tested for their antifungal activity.
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