AI Article Synopsis
- Urine from prostate cancer patients contains unique biopolymers, such as protein- and microvesicle-associated miRNAs, that could serve as potential markers for cancer diagnosis.
- In our research, we compared the expression of 84 miRNAs in urine microvesicles and clarified urine from healthy individuals, those with benign conditions, and prostate cancer patients using specialized miRNA testing.
- We found distinct subsets of miRNAs with varying expression levels in each group, revealing two main groups of miRNAs that influence important signaling pathways related to the development of prostate cancer.
Article Abstract
Urine of prostate cancer patients contains tumor-specific biopolymers, including protein- and microvesiclesassociated miRNAs that can potentially be used as oncomarkers. Previously we have characterized urine extracellular vesicles and demonstrated diagnostic potential of their miRNA cargo. In this study, we have performed a comparative analysis of the expression of 84 miRNA in paired samples of urine microvesicles and clarified urine from healthy men, patients with benign hyperplasia and cancer of the prostate using miRCURY LNA miRNA qPCR Panels. Subsets of miRNAs with differences in expression between the fractions of the urine were found in all three groups. Two groups of miRNA were identified based on the patterns of their differential expression. They regulate several key signaling pathways associated with prostate cancer development.
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| http://dx.doi.org/10.18097/PBMC20186401038 | DOI Listing |
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