AI Article Synopsis
- Initial complications of enteral nutrition (EN) include vomiting, aspiration pneumonia, and diarrhea, prompting the exploration of a viscosity-regulating pectin solution to mitigate these issues.
- A study involving 34 patients from 7 medical institutions compared the effects of this novel pectin solution (VREF group) with conventional EN methods (control group) over two weeks, monitoring various clinical symptoms and stool characteristics.
- Results showed a favorable trend in clinical symptoms and a reduction in infusion duration for the VREF group, indicating that this new method can be safely and effectively integrated into EN management, similar to traditional approaches.
Article Abstract
Background & Aims: The initial complications associated with infusion of enteral nutrition (EN) for clinical and nutritional care are vomiting, aspiration pneumonia, and diarrhea. There are many recommendations to prevent these complications. A novel method involving a viscosity-regulating pectin solution has been demonstrated. In Japan, this method along with the other so-called "semi-solid EN" approaches has been widely used in practice. However, there has been no randomized clinical trial to prove the efficiency and safety of a viscosity-regulating pectin solution in EN management. Therefore, we planned and initiated a multicenter randomized controlled trial to determine the efficiency and safety.
Methods: This study included 34 patients from 7 medical institutions who participated. Institutional review board (IRB) approval was obtained from all participating institutions. Patients who required EN management were enrolled and randomly assigned to the viscosity regulation of enteral feeding (VREF) group and control group. The VREF group (n = 15) was managed with the addition of a viscosity-regulating pectin solution. The control group (n = 12) was managed with conventional EN administration, usually in a gradual step-up method. Daily clinical symptoms of pneumonia, fever, vomiting, and diarrhea; defecation frequency; and stool form were observed in the 2 week trial period. The dose of EN and duration of infusion were also examined.
Results: A favorable trend for clinical symptoms was noticed in the VREF group. No significant differences were observed in episodes of pneumonia, fever, vomiting, and diarrhea between the 2 groups. An apparent reduction in infusion duration and hardening of stool form were noted in the VREF group.
Conclusions: The novel method involving a viscosity-regulating pectin solution with EN administration can be clinically performed safely and efficiently, similar to the conventional method. Moreover, there were benefits, such as improvement in stool form, a short time for EN infusion, and a reduction in vomiting episodes, with the use of the novel method. This indicates some potential advantages in the quality of life among patients receiving this novel method.
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| http://dx.doi.org/10.1016/j.clnesp.2017.11.005 | DOI Listing |
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