AI Article Synopsis
- - Early diagnosis of atherosclerosis is important in medicine, but it's a complex disease influenced by multiple factors.
- - Asiaticoside (AA), a compound from Centella asiatica, has anti-inflammatory properties and was tested on human umbilical endothelial cells exposed to oxidized LDL-induced inflammation.
- - The study found that AA significantly reduced endothelial permeability and levels of certain adhesion molecules (like ICAM-1 and VCAM-1), suggesting it may help prevent early stages of atherosclerosis.
Article Abstract
Early diagnosis and changes associated with atherosclerosis are crucial in clinical medicine. However, atherosclerosis is a multifactorial disease. Asiaticoside (AA), a triterpenoid derived from Centella asiatica, has anti-inflammatory activity. Endothelium-derived nitric oxide is important in modulating vascular tone in a distinct vessel size-dependent manner; it plays a dominant role in conduit arteries and endothelium-dependent hyperpolarisation in resistance vessels. This study evaluated the effects of AA administration on human umbilical endothelial cells with oxidised low-density lipoprotein-induced inflammation. We measured the levels of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1). Our results indicated that 10-30 μM AA modulated endothelial hyper permeability, adenosine triphosphate levels, ICAM-1 expression, VCAM-1 expression, E-selectin levels, and PECAM-1 expression to 90% (p < 0.005), 80% (p < 0.05), 105% (p < 0.01), 65% (p < 0.005), 70% (p < 0.05), and 105% (p < 0.01), respectively. Taken together, our data suggest that AA inhibits the augmentation of endothelial permeability, thus preventing the early events of atherosclerosis.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5851977 | PMC |
| http://dx.doi.org/10.1007/s10616-018-0198-4 | DOI Listing |
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