Purpose: To find differences in epithelial thickness (ET) maps of eyes with keratoconus (KC) and healthy eyes.
Design: Institutional cross-sectional study.
Methods: In this study 40 keratoconic eyes and 76 healthy eyes were scanned using a custom-built ultrahigh-resolution optical coherence tomography system. Automated segmentation ET maps with 17 subsectors were calculated (central, temporal inferior, temporal superior, nasal inferior, and nasal superior area). The thinnest point of the epithelium (minET), the thickest point of the epithelium (maxET), and the thinnest point diagonally opposing the thickest point (ET) were additional parameters. Ratios were calculated as follows: minET/diagonally opposing point (R), maxET/diagonally opposing point (R), inferior temporal area/superior nasal area (R), and inferior/superior hemisphere (R). Furthermore, collected parameters were analyzed regarding their diagnostic accuracy (area under the curve; AUC).
Results: Statistically significant differences were as follows: central ET, 46.25 ± 2.56/50.91 ± 1.66; minET, 38.50 ± 2.10/46.79 ± 1.27; ET, 47.14 ± 2.45/49.60 ± 1.57; temporal inferior area: 43.93 ± 2.95/51.04 ± 1.51 (all mean ± standard deviation, μm); R, 0.76 ± 0.09/0.93 ± 0.04; R, 1.08 ± 0.04/1.21 ± 0.16; R, 0.85 ± 0.08/1.02 ± 0.04; R: 0.92 ± 0.07/0.99 ± 0.02. AUC values were R: 0.979 (confidence interval [CI]: 0.957-1.000), R: 0.977 (CI: 0.951-1.000), and minET: 0.928 (CI: 0.880-0.977).
Conclusions: Epithelial thickness maps could clearly visualize different ET patterns. Parameters with the highest potential of diagnostic discrimination between eyes with KC and healthy eyes were, in descending order, R, R, and minET. Consequently, epithelial thickness irregularity and asymmetry seem to be the most promising diagnostic factor in terms of discriminating between keratoconic eyes and healthy eyes.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.ajo.2018.02.006 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Eye Movements and the Intraorbital Subarachnoid Space: Potential Contribution of Altered Cerebrospinal Fluid Pumping in Optic Neuropathies.
Invest Ophthalmol Vis Sci
January 2025
Department of Ophthalmology, University of California, Los Angeles, California, United States.
Purpose: The optic nerve (ON) is mechanically perturbed by eye movements that shift cerebrospinal fluid (CSF) within its surrounding dural sheath. This study compared changes in ON length and CSF volume within the intraorbital ON sheath caused by eye movements in healthy subjects and patients with optic neuropathies.
Methods: Twenty-one healthy controls were compared with 11 patients having primary open angle glaucoma (POAG) at normal intraocular pressure (IOP), and 11 with chronic non-arteritic anterior ischemic optic neuropathy (NA-AION).
Normalized Reflectivity of Middle Limiting Membrane on SD-OCT: A Measure of Acute Ischemia in CRVO.
Curr Eye Res
January 2025
Department of Ophthalmology, University Medical Center Goettingen, Goettingen, Germany.
Purpose: To validate the quantification of the prominent middle limiting membrane (PMLM) sign, a marker of mild-to-moderate acute ischemic damage on optical coherence tomography (OCT), by measuring middle limiting membrane (MLM) reflectivity in patients with central retinal vein occlusion (CRVO) and to investigate the prognostic impact of this measure.
Methods: Spectral Domain (SD)-OCT B-scans of 30 patients with CRVO, either sole CRVO or combined central retinal artery and vein occlusion (CCRAVO), were analyzed retrospectively and graded as PMLM present or absent. Normalized MLM reflectivity was calculated as a ratio of the maximum reflectivity within a MLM target layer and the average reflectivity of the retinal pigment epithelium (RPE).
Eeg Microstates and Balance Parameters for Stroke Discrimination: A Machine Learning Approach.
Brain Topogr
January 2025
Aging and Neuroscience Laboratory (LABEN), Federal University of Paraíba, João Pessoa, PB, Brazil.
Electroencephalography microstates (EEG-MS) show promise to be a neurobiological biomarker in stroke. Thus, the aim of the study was to identify biomarkers to discriminate stroke patients from healthy individuals based on EEG-MS and clinical features using a machine learning approach. Fifty-four participants (27 stroke patients and 27 healthy age and sex-matched controls) were recruited.
View Article and Find Full Text PDFDisrupted microsaccade responses in late-life depression.
Sci Rep
January 2025
Department of Anesthesiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei City, Taiwan.
Late-life depression (LLD) is a psychiatric disorder in older adults, characterized by high prevalence and significant mortality rates. Thus, it is imperative to develop objective and cost-effective methods for detecting LLD. Individuals with depression often exhibit disrupted levels of arousal, and microsaccades, as a type of fixational eye movement that can be measured non-invasively, are known to be modulated by arousal.
View Article and Find Full Text PDFEvaluation of colour vision impairment during acute hypobaric hypoxia in aviation medicine: a randomized controlled trial.
J Physiol Sci
January 2025
Johannes Wesling Klinikum Minden, University Hospital, Ruhr University Bochum, Bochum, Germany.
The digitization of aircraft cockpits places high demands on the colour vision of pilots. The present study investigates colour vision changes upon acute exposure to hypobaric hypoxia. The digital Waggoner Computerized Color Vision Test and the Waggoner D-15 were performed by 54 healthy volunteers in a decompression chamber.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!