AI Article Synopsis
- * The GTPase Rap1 is crucial for this process as it helps in remodeling the actin network and directing the microtubule-organizing center (MTOC) towards the antigen.
- * Research shows that Rap2c, another GTPase, also plays a role in MTOC polarization and actin remodeling, indicating that Rap1 and Rap2 proteins work together but have distinct, non-overlapping functions.
Article Abstract
When B lymphocytes encounter antigen-bearing surfaces, B-cell receptor (BCR) signaling initiates remodeling of the F-actin network and reorientation of the microtubule-organizing center (MTOC) towards the antigen contact site. We have previously shown that the Rap1 GTPase, an evolutionarily conserved regulator of cell polarity, is essential for these processes and that Rap1-regulated actin remodeling is required for MTOC polarization. The role of Rap2 proteins in establishing cell polarity is not well understood. We now show that depleting Rap2c, the only Rap2 isoform expressed in the A20 B-cell line, impairs BCR-induced MTOC reorientation as well as the actin remodeling that supports MTOC polarization. Thus Rap1 and Rap2 proteins may have similar but non-redundant functions in coupling the BCR to MTOC polarization.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7549615 | PMC |
| http://dx.doi.org/10.1080/21541248.2018.1441626 | DOI Listing |
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