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Dysregulation of REST and its target genes impacts the fate of neural progenitor cells in down syndrome.
Sci Rep
January 2025
Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, 43400, Selangor, Malaysia.
Increasing shreds of evidence suggest that neurogenic-to-gliogenic shift may be critical to the abnormal neurodevelopment observed in individuals with Down syndrome (DS). REST, the Repressor Element-1 Silencing Transcription factor, regulates the differentiation and development of neural cells. Downregulation of REST may lead to defects in post-differentiation neuronal morphology in the brain of the DS fetal.
View Article and Find Full Text PDFDecoding brain structure to stage Alzheimer's disease pathology in Down syndrome.
Alzheimers Dement
January 2025
Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA.
Introduction: Alzheimer's disease (AD) in Down syndrome (DS) is associated with changes in brain structure. It is unknown if thickness and volumetric changes can identify AD stages and if they are similar to other genetic forms of AD.
Methods: Magnetic resonance imaging scans were collected for 178 DS adults (106 nonclinical, 45 preclinical, and 27 symptomatic).
Direct Evaluation of Salivary Antioxidant Properties in Patients with Down Syndrome for assessment to Periodontal Disease and Premature Aging.
Free Radic Biol Med
January 2025
Department of Disaster Related Oral Health & Oxidative Stress/ESR Laboratories, Kanagawa Dental University, 82 Inaoka-cho, Yokosuka, Kanagawa 238-8580, Japan. Electronic address:
To evaluate oxidative stress involved in Down syndrome periodontal disease and pathological premature aging, reactive oxygen species (ROS) such as superoxide (O) and hydroxyl radical (HO) in human saliva were measured using electron spin resonance (ESR) spectroscopy. The groups consisted of 20 subjects in the Down syndrome (DS) child (DC) group (mean age 11.3 ± 4.
View Article and Find Full Text PDFRaising awareness and addressing inequities for people with Down syndrome in South Africa.
Int J Equity Health
January 2025
Tekano, Capetown, South Africa.
Globally, individuals with Down syndrome (DS) face profound inequities in social and health care access. These challenges are further compounded by racial disparities as well as a lack of awareness, research, and support, particularly in the Global South. This commentary discusses the multifaceted challenges and disparities encountered by people with DS in South Africa, highlighting the need for targeted interventions.
View Article and Find Full Text PDFLithium restores nuclear REST and Mitigates oxidative stress in down syndrome iPSC-Derived neurons.
Neuroscience
January 2025
Department of Human Anatomy, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400, UPM, Serdang, Selangor, Malaysia; Malaysian Research Institute on Ageing (MyAgeing(TM)), Universiti Putra Malaysia, 43400, UPM, Serdang, Selangor, Malaysia. Electronic address:
Article Synopsis
- Down syndrome (DS) is linked to trisomy 21, leading to intellectual disabilities and increased oxidative stress, impacting neuronal health.
- REST is a key protein involved in regulating genes related to DS neuropathology, and this study explores lithium’s effects on restoring REST levels in DS neurons.
- Results indicated that lithium treatment restored nuclear REST levels and significantly reduced reactive oxygen species (ROS) in DS neurons, suggesting potential therapeutic benefits of lithium for improving neuronal function in Down syndrome.
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