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http://dx.doi.org/10.1111/cen.13577 | DOI Listing |
Clin Endocrinol (Oxf)
May 2018
Department of Endocrinology, Royal Devon and Exeter NHS Foundation Trust, Exeter, UK.
Eur J Med Chem
November 2017
Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, PR China. Electronic address:
There is considerable interest in developing new SERMs as multifunctional agents in women's health. Development of dual selective estrogen receptor modulators/VEGFR-2 inhibitors (SERMs/V-2I) has been an attractive strategy for the discovery of new breast cancer therapeutic agents. Our previous efforts led to the preparation of a series of 3-aryl-4-anilino-2H-chromen-2-ones endowed with potent estrogen receptor binding affinity and anti-proliferative efficacy.
View Article and Find Full Text PDFJ Neurosci
October 2007
Department of Pathology, New York Medical College, Westchester Medical Center, Valhalla, New York 10595, USA.
Germinal matrix (GM) is a richly vascularized collection of neuronal-glial precursor cells in the developing brain, which is selectively vulnerable to hemorrhage in premature infants. It has rapid angiogenesis associated with high levels of vascular endothelial growth factor (VEGF). Because pericytes provide structural stability to blood vessels, we asked whether pericytes were fewer in the GM than in the subjacent white matter and neocortex and, if so, whether angiogenic inhibition could increase the pericyte density in the GM.
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