Neuroectodermally Derived Neoplasm of Tonsil: Difficulty in Histomorphological Diagnosis.

Indian J Otolaryngol Head Neck Surg

Department of Pathology, Kovai Medical Center and Hospital, Coimbatore, Tamilnadu India.

Published: March 2018

Esthesioneuroblastomas are rare neuroectodermally derived neoplasms occurring in the upper nasal septum or cribriform plate. They have been rarely reported in other sites, when they are called ectopic esthesioneuroblastomas. Due to the scarcity of reports, publications and molecular/genetic studies of these tumours, their diagnosis is likely to be missed when they are ectopic. Similar to the case report in this journal by Zahedi et al., we had a case of neuroectodermally derived neoplasm of the tonsil, which was difficult to diagnose, due to the site of occurrence being unknown for these tumours.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5807285PMC
http://dx.doi.org/10.1007/s12070-017-1172-8DOI Listing

Publication Analysis

Top Keywords

neuroectodermally derived
12
derived neoplasm
8
neoplasm tonsil
8
tonsil difficulty
4
difficulty histomorphological
4
histomorphological diagnosis
4
diagnosis esthesioneuroblastomas
4
esthesioneuroblastomas rare
4
rare neuroectodermally
4
derived neoplasms
4

Similar Publications

Embryonic-type neuroectodermal tumors (ENTs) arising from testicular germ cell tumors (GCTs) is a relatively common type of somatic transformation in GCTs with poor prognosis and limited therapeutic options, particularly when patients develop disease recurrence or metastasis. Knowledge of key events driving this transformation is limited to the paucity of comprehensive genomic data. We performed a retrospective database search in a CLIA- and CAP-certified laboratory for testicular GCT-derived ENTs that had previously undergone NGS-based comprehensive genomic profiling during the course of clinical care.

View Article and Find Full Text PDF

In recent years, the progression of stem cell therapies has shown great promise in advancing the nascent field of regenerative medicine. Considering the non-regenerative nature of the mature central nervous system, the concept that "blank" cells could be reprogrammed and functionally integrated into host neural networks remained intriguing. Previous work has also demonstrated the ability of such cells to stimulate intrinsic growth programs in post-mitotic cells, such as neurons.

View Article and Find Full Text PDF

Lineage labeling with zebrafish Cre and CreERT2 recombinase CRISPR knock-ins.

bioRxiv

December 2024

Department of Genetics, Development and Cell Biology, Iowa State University, Ames, Iowa 50011-1101 USA.

Background: The ability to generate endogenous Cre recombinase drivers using CRISPR-Cas9 knock-in technology allows lineage tracing, cell type specific gene studies, and validation of inferred developmental trajectories from phenotypic and gene expression analyses. This report describes endogenous zebrafish Cre and CreERT2 drivers generated with GeneWeld CRISPR-Cas9 precision targeted integration.

Results: and knock-ins crossed with ubiquitous -based Switch reporters led to broad labeling in expected mesodermal and neural crest-derived lineages in cardiac, pectoral fins, pharyngeal arch, liver, intestine, and mesothelial tissues, as well as enteric neurons.

View Article and Find Full Text PDF

Generation, interrogation, and future applications of microglia-containing brain organoids.

Neural Regen Res

December 2024

Laboratory of Experimental Hematology, Vaccine and Infectious Disease Institute (Vaxinfectio), University of Antwerp, Wilrijk, Belgium.

Brain organoids encompass a large collection of in vitro stem cell-derived 3D culture systems that aim to recapitulate multiple aspects of in vivo brain development and function. First, this review provides a brief introduction to the current state-of-the-art for neuro-ectoderm brain organoid development, emphasizing their biggest advantages in comparison with classical two-dimensional cell cultures and animal models. However, despite their usefulness for developmental studies, a major limitation for most brain organoid models is the absence of contributing cell types from endodermal and mesodermal origin.

View Article and Find Full Text PDF
Article Synopsis
  • The processes of primary and secondary neurulation, which lead to spinal cord formation, are not fully understood in humans due to difficulties accessing embryos at the relevant stages (3-7 weeks post-conception).
  • Analysis of 108 human embryos reveals that while primary neurulation is similar to that in mice, it has distinct differences; secondary neurulation begins later and forms a single lumen, unlike the multiple lumens seen in chicks.
  • Key differences in neurulation timing between humans and mice were noted, such as the rate of somite formation and the termination of axial elongation associated with apoptosis in the embryonic tailbud; these findings can aid current research on neurulation using stem cell-derived organoids
View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!