AI Article Synopsis
- The study explores the need for effective tuberculosis (TB) vaccines and how polymer-based delivery systems can enhance their immunogenicity to address existing challenges in vaccine development.
- A comprehensive literature review identified 31 relevant studies that demonstrated the effectiveness of various polymeric particles, like PLGA and chitosan, in improving immune responses and offering long-lasting protection against TB in animal models.
- The findings suggest that while biodegradable polymers are more commonly used for TB vaccines, there’s a need for further research into non-biodegradable synthetic polymers as potential adjuvants.
Article Abstract
Objectives: Production of effective tuberculosis (TB) vaccine is necessity. However, the development of new subunit vaccines is faced with concerns about their weak immunogenicity. To overcome such problems, polymers-based vaccine delivery systems have been proposed to be used via various routes. The purpose of this study was to determine the potential of polymeric particles as future vaccine delivery systems/adjuvants for parenteral and non-parenteral immunization against TB.
Materials And Methods: PubMed, Scopus, Science-Direct, and the ISI web of knowledge databases were searched for related keywords. A total of 420 articles, written up to June 25, 2016, were collected on the potential of polymeric particles as TB vaccine delivery systems after parenteral and non-parenteral immunization. Thirty-one relevant articles were selected by applying inclusion and exclusion criteria.
Results: It was shown that the immunogenicity of TB vaccines had been improved by using biodegradable and non-biodegradable synthetic polymers as well as natural polymers and they are better able to enhance the humoral and cellular immune responses, compared to TB vaccines alone. The present study revealed that various polymeric particles, after challenge in animal models, provide long-lasting protection against TB. PLGA (poly (lactide-co-glycolide)) and chitosan polymers were widely used as TB vaccine delivery systems/adjuvants.
Conclusion: It seems that PLGA and chitosan polymers are well-suited particles for the parenteral and non-parenteral administration of TB vaccines, respectively. Non-biodegradable synthetic polymers in comparison with biodegradable synthetic and natural polymers have been used less frequently. Therefore, further study on this category of polymers is required.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5811749 | PMC |
| http://dx.doi.org/10.22038/IJBMS.2017.22059.5648 | DOI Listing |
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