Objective/background: In a pilot study, a relationship between abdominal aortic aneurysm (AAA) diameter and serum interleukin (IL)-1α levels was reported, and that endothelial cell (EC) activation in vitro in response to serum from patients with AAA was blocked by anti-IL-1α antibodies. The aim of the present study was to further investigate the relationship between serum IL-1α and asymptomatic infrarenal AAA size, morphology, and growth rates.
Methods: Serum IL-1α was measured using enzyme linked immunosorbent assay in 101 patients with asymptomatic, infrarenal AAA and related to aneurysm size, morphology, and growth rates.
Results: IL-1α was measured in 101 patients. There was no statistically significant difference in mean age between men and women. IL-1α was detectable in 62.4% of patients; median IL-1α titre was 3.26 pg/mL. There was no statistically significant relationship between IL-1α and maximum AAA antero-posterior diameter as measured by ultrasound (p = .649), AAA morphology (aortic length [p = .394], sac [p = .369], and thrombus volume [p = .629]) as measured on computed tomography, absolute increase in AAA diameter (p = .214), or AAA growth rate (p = .230).
Conclusion: IL-1α is detectable in the majority of patients with infrarenal AAA, but the cause and clinical significance of this novel observation remains unknown.
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http://dx.doi.org/10.1016/j.ejvs.2018.01.015 | DOI Listing |
Ann Vasc Dis
December 2024
Department of Anesthesiology, Kochi Medical School, Nankoku, Kochi, Japan.
With improved surgical outcomes for non-ruptured abdominal aortic aneurysm (AAA), the primary objective has shifted toward the detection of asymptomatic AAA. Since ultrasonographic visualization from the anterior abdominal wall is often obstructed by intestinal gas, utilizing additional bilateral posterior approaches via the retroperitoneal tissue may be beneficial. This study investigates the feasibility of assessment using three approaches through computed tomography (CT) data analyses.
View Article and Find Full Text PDFEur J Vasc Endovasc Surg
December 2024
Department of Vascular Surgery, University Hospital of Rangueil, Toulouse, France.
Objective: Coral reef atherosclerosis of the visceral aorta (CRA) is associated with renovascular hypertension (RVH), chronic mesenteric ischaemia (CMI), and malperfusion of the lower limbs (PAD). The outcomes of open surgery for this rare disease are described in this paper.
Methods: This retrospective study included all patients who underwent open surgical repair of CRA at a single high volume referral centre between January 2009 and June 2023.
Eur J Pharmacol
January 2025
Department of Pharmacology, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, 410013, Hunan, China; Hunan Provincial Key Laboratory of Cardiovascular Research, Central South University, Changsha, 410013, Hunan, China. Electronic address:
EJVES Vasc Forum
September 2024
Department of Vascular Surgery, Ospedale Cardinal Massaia, Asti, Italy.
Introduction: Endovascular aneurysm repair (EVAR) is a safe and widespread treatment option for abdominal aortic aneurysm (AAA). Unfavourable anatomy, such as hostile neck and aorto-iliac atherosclerosis, can lead to many complications and compromise the long term reliability of the endograft, resulting in a high rate of EVAR failure. Intravascular lithotripsy (IVL) has emerged as an alternative treatment to address severe iliofemoral atherosclerosis, aiding trackability of devices in EVAR.
View Article and Find Full Text PDFCatheter Cardiovasc Interv
November 2024
Department of Cardiology and Intensive Care Medicine, Kepler University Hospital, Medical Faculty, Johannes Kepler University, Linz, Austria.
Transfemoral aortic valve replacement (TAVR) is an effective way to treat severe aortic valve stenosis, especially in patients who are high-risk for surgery. Dislocation of an endoluminal aortic bifurcation stent graft during TAVR is an extremely rare complication. We present a case on how management of this complication was successfully done.
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