AI Article Synopsis

  • The study aimed to explore the connection between serum interleukin (IL)-1α levels and various characteristics of asymptomatic infrarenal abdominal aortic aneurysms (AAA), including their size, shape, and growth rates.
  • IL-1α levels were measured in 101 patients, revealing that while it was detectable in 62.4% of cases, there was no significant association between IL-1α levels and AAA size or growth.
  • The findings suggest that although IL-1α is frequently present in patients with infrarenal AAA, its role and importance in relation to the aneurysm's characteristics are still unclear.

Article Abstract

Objective/background: In a pilot study, a relationship between abdominal aortic aneurysm (AAA) diameter and serum interleukin (IL)-1α levels was reported, and that endothelial cell (EC) activation in vitro in response to serum from patients with AAA was blocked by anti-IL-1α antibodies. The aim of the present study was to further investigate the relationship between serum IL-1α and asymptomatic infrarenal AAA size, morphology, and growth rates.

Methods: Serum IL-1α was measured using enzyme linked immunosorbent assay in 101 patients with asymptomatic, infrarenal AAA and related to aneurysm size, morphology, and growth rates.

Results: IL-1α was measured in 101 patients. There was no statistically significant difference in mean age between men and women. IL-1α was detectable in 62.4% of patients; median IL-1α titre was 3.26 pg/mL. There was no statistically significant relationship between IL-1α and maximum AAA antero-posterior diameter as measured by ultrasound (p = .649), AAA morphology (aortic length [p = .394], sac [p = .369], and thrombus volume [p = .629]) as measured on computed tomography, absolute increase in AAA diameter (p = .214), or AAA growth rate (p = .230).

Conclusion: IL-1α is detectable in the majority of patients with infrarenal AAA, but the cause and clinical significance of this novel observation remains unknown.

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Source
http://dx.doi.org/10.1016/j.ejvs.2018.01.015DOI Listing

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