AI Article Synopsis
- * Cytotoxicity tests showed that compound 11 was highly effective against multiple cancer cell lines, while compounds 5 and 13 promoted nerve growth factor release in a specific rat cell line.
- * Further evaluation of anti-inflammatory properties revealed that compounds 7 and 12 significantly inhibited nitric oxide production in activated BV-2 cells without causing notable cell toxicity.
Article Abstract
Investigation of the MeOH extract of Betula schmidtii twigs resulted in the isolation and identification of three new triterpenoids (1-3), along with ten known ones (4-13). The structures of new compounds (1-3) were elucidated by spectroscopic methods, including 1D, 2D NMR (H and C NMR, COSY, HSQC, HMBC, and NOESY), HR-MS, and chemical methods. All the isolated compounds were evaluated for their cytotoxicity against A549, SK-OV-3, SK-MEL-2, and HCT-15 cell lines. Compound 11 exhibited potent cytotoxic activities against four cell lines, and compounds 5 and 13 significantly induced nerve growth factor secretion in a C6 rat glioma cell line. Their anti-inflammatory effects were also assessed by measuring nitric oxide production in lipopolysaccharide-activated BV-2 cells. Compounds 7 and 12 displayed potent inhibition of nitric oxide production, without significant cell toxicity.
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| http://dx.doi.org/10.1016/j.bioorg.2018.02.006 | DOI Listing |
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