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HSF4 transcriptional regulates HMOX-1 expression in HLECs. | LitMetric

HSF4 transcriptional regulates HMOX-1 expression in HLECs.

Gene

Key Laboratory of Protein Modification and Tumor, Hubei Polytechnic University School of Medicine, Huangshi, Hubei 435003, PR China; Huangshi Maternity and Children's Health Hospital, Edong Healthcare Group, Huangshi, Hubei 435003, China; The Fourth Hospital of Huangshi, Huangshi, Hubei 435003, PR China. Electronic address:

Published: May 2018

AI Article Synopsis

Article Abstract

The major causes for cataract formation are free radicals, which are neutralized by the endogenous antioxidants. However, how the human lens clean these harmful free radicals is still unclear. Transcriptional factor heat shock factor 4 (HSF4) is a cataract-causing gene and plays important roles during lens development. Here we show that HMOX-1, an anti-oxidase, is a bona fide transcriptional target gene of HSF4 in HLECs (human lens epithelial cells). HSF4 directly binds to the HSE element in HMOX-1 promoter to mediate its mRNA transcription and protein accumulation. The HSE element located at the region of -389 bp to -362 bp upstream from the TSS (transcription start site), which is critical for HMOX-1 transcriptional activation. Furthermore, knockdown of HSF4 by siRNA inhibited HMOX-1 expression. Thus, these data revealed a novel transcription target of HSF4 and provided new insights into anti-oxidation regulation in lens and age-related cataract.

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Source
http://dx.doi.org/10.1016/j.gene.2018.02.033DOI Listing

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