AI Article Synopsis
- A study was conducted to understand how genetic factors influence sperm motility, which is important for fertilization and affected by lifestyle and environmental influences.
- Researchers performed a two-stage genome-wide association study (GWAS) with over 1,500 Japanese men to identify genetic differences related to sperm movement.
- The study found a significant genetic variant (rs3791686) linked to sperm motility, suggesting a novel target for further investigation into the genetic underpinnings of fertility.
Article Abstract
Background: The decrease in sperm motility has a potent influence on fertilisation. Sperm motility, represented as the percentage of motile sperm in ejaculated sperms, is influenced by lifestyle habits or environmental factors and by inherited factors. However, genetic factors contributing to individual differences in sperm motility remain unclear. To identify genetic factors that influence human sperm motility, we performed a genome-wide association study (GWAS) of sperm motility.
Methods: A two-stage GWAS was conducted using 811 Japanese men in a discovery stage, followed by a replication study using an additional 779 Japanese men.
Results: In the two-staged GWAS, a single nucleotide polymorphism rs3791686 in the intron of gene for erb-b2 receptor tyrosine kinase 4 () on chromosome 2q34 was identified as a novel locus for sperm motility, as evident from the discovery and replication results using meta-analysis (β=-4.01, combined P=5.40×10).
Conclusions: Together with the previous evidence that Sertoli cell-specific -knockout mice display an impaired ability to produce motile sperm, this finding provides the first genetic evidence for further investigation of the genome-wide significant association at the locus in larger studies across diverse human populations.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5992371 | PMC |
| http://dx.doi.org/10.1136/jmedgenet-2017-104991 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Seroprevalence of HSV-2 in multiple subgroups of infertile men with abnormal sperm parameters and those seeking sex selection: a case-control study.
BMC Infect Dis
January 2025
Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran.
Background: Herpes simplex virus type 2 (HSV-2) is a common sexually transmitted infection (STI) primarily acquired through sexual contact. In 2000, the World Health Organization (WHO) for the first time reported the association of STIs with male infertility. Infertility is described as the inability to achieve a clinical pregnancy after engaging in regular, unprotected sexual intercourse for a year or more.
View Article and Find Full Text PDFEffect of in vitro exposure of first-line antiretrovirals on healthy human spermatozoa on kinematics and motility.
Int Urol Nephrol
January 2025
Department of Urology, Faculty of Health Sciences, Steve Biko Academic Hospital, University of Pretoria, Pretoria, South Africa.
Purpose: Contemporary antiretroviral (ARV) medications are used by millions of men for HIV treatment worldwide. Limited data exist on their direct effect on sperm motility. This pilot study hypothesizes that in vitro exposure to ARVs will reduce sperm kinematic and motility parameter values.
View Article and Find Full Text PDFRole of GPR55 receptor in bovine sperm capacitation.
Andrology
January 2025
Centro de Estudios Farmacológicos y Botánicos (CEFYBO), Facultad de Medicina-Universidad de Buenos Aires (UBA/CONICET), Buenos Aires, Argentina.
Background: Endocannabinoids like anandamide (AEA), among other lipids, are recognized signaling molecules that participate in reproductive events.
Objectives: Our aims were to characterize orphan G protein-coupled receptor (GPR55) presence; investigate GPR55 activation by AEA and determine GPR55 role in the bovine sperm function.
Materials And Methods: GPR55 presence was assessed by immunocytochemistry.
By ameliorating redox imbalance, patients of oligoasthenospermia increased sperm acrosin activity after smoking cessation in Chinese.
Rev Int Androl
December 2024
Wuxi School of Medicine, Jiangnan University, 214002 Wuxi, Jiangsu, China.
Background: The massive harmful effects of cigarette (tobacco) smoking on reproduction and fecundity are apparent. Even smoking cessation is often suggested for infertility patients by clinic doctors, while the impact of smoking cessation on semen quality in patients with oligoasthenospermia is uncovered.
Methods: Ninety oligoasthenospermia patients with long tobacco smoking history were directed by andrology doctors to cease smoking, and their cessation was followed up for 3 to 6 months.
Laptop and tablet use and their influence on total motile sperm count parameters: are laptops linked to infertility in Jamaican men?
Rev Int Androl
December 2024
The Department of Physics, The University of the West Indies, Mona Campus, KGN7 Kingston, Jamaica.
Background: This study aims to determine the impact of laptop and tablet use on total motile sperm count (TMSC) in men being investigated for assisted reproduction.
Methods: A cross-sectional study was conducted on 156 men attending a fertility clinic in Jamaica. Routine semen analyses were performed and parameters specific to TMSC assessed.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!