AI Article Synopsis
- The rise in opportunistic fungal infections is linked to more people being immunocompromised due to modern medicine and the HIV/AIDS crisis.
- The study highlights the importance of the fungal cell wall, which protects fungi and interacts with the immune system, affecting their ability to cause disease.
- New research reveals how environmental factors influence fungal ability to evade the immune system, and understanding these signaling pathways could help develop new treatments to improve immune responses.
Article Abstract
Deadly infections from opportunistic fungi have risen in frequency, largely because of the at-risk immunocompromised population created by advances in modern medicine and the HIV/AIDS pandemic. This review focuses on dynamics of the fungal polysaccharide cell wall, which plays an outsized role in fungal pathogenesis and therapy because it acts as both an environmental barrier and as the major interface with the host immune system. Human fungal pathogens use architectural strategies to mask epitopes from the host and prevent immune surveillance, and recent work elucidates how biotic and abiotic stresses present during infection can either block or enhance masking. The signaling components implicated in regulating fungal immune recognition can teach us how cell wall dynamics are controlled, and represent potential targets for interventions designed to boost or dampen immunity.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869159 | PMC |
| http://dx.doi.org/10.1016/j.tim.2018.01.007 | DOI Listing |
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