Selective leads: In this study, we generated a new series of serotonin 5-HT receptor antagonists. Their synthesis, structure-activity relationships, and selectivity profiles are reported. This series includes 5-HT antagonists with unprecedented high selectivity for the 5-HT receptor, setting the stage for lead optimization of drugs acting on a range of neurological targets.
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| http://dx.doi.org/10.1002/cmdc.201800026 | DOI Listing |
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