[DNA sequencing by nanopores: achievements and prospects].

Med Sci (Paris)

Univ Lyon, Ens de Lyon, Univ Claude Bernard, CNRS, Laboratoire de Physique, 46, allée d'Italie, F-69342 Lyon, France.

Published: February 2018

After years of development, the use of nanopore as a sensor to sequence DNA molecules is now a viable and promising possibility. Single base pair detection during DNA transport enables to record ultra-long threads with high parallelization and rates. I will present in this review the current methodologies based on electrical detection and biological nanopores and the new methods based on solid state nanopores and optical detection.

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http://dx.doi.org/10.1051/medsci/20183402014DOI Listing

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