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Functional and Cognitive Impairment in Patients with Relapsing-Remitting Multiple Sclerosis: Cognitive Tests and Plasma Neurofilament Light Chain Levels.
Medicina (Kaunas)
January 2025
Department of Neurology and Neurosurgery, Riga East University Hospital, LV-1038 Riga, Latvia.
Multiple sclerosis (MS) is a chronic inflammatory, autoimmune, and neurodegenerative disease of the central nervous system. The disease can manifest and progress with both physical and cognitive symptoms, affecting the patient's daily activities. The aim of our study was to investigate the correlation between functional status, cognitive functions, and neurofilament light chain levels in plasma in MS patients.
View Article and Find Full Text PDFEfficacy and Safety Results With Rilzabrutinib, an Oral Bruton Tyrosine Kinase Inhibitor, in Patients With Immune Thrombocytopenia: Phase 2 Part B Study.
Am J Hematol
January 2025
Hematology Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Current treatments for persistent or chronic immune thrombocytopenia (ITP) are limited by inadequate response, toxicity, and impaired quality of life. The Bruton tyrosine kinase inhibitor rilzabrutinib was evaluated to further characterize safety and durability of platelet response. LUNA2 Part B is a multicenter, phase 1/2 study in adults with ITP (≥ 3 months duration, platelet count < 30 × 10/L) who failed ≥ 1 ITP therapy (NCT03395210, EudraCT 2017-004012-19).
View Article and Find Full Text PDF[Evaluation of the psychometric properties of the 8-item Morisky medication adherence scale (MMAS-8) for oral anticoagulants in the Spanish population].
Semergen
January 2025
Departamento de Psicología de la Salud, Universidad Miguel Hernández, Elche, Alicante, España.
Aim: The use of oral anticoagulants has increased due to the rising prevalence of auricular fibrillation, a condition that raises the risk of thromboembolic events. These drugs are effective in preventing such events, but their success depends on therapeutic adherence, which requires validated tools for assessment. The aim of this study is to evaluate the suitability of the Morisky Medication Adherence Scale-8 (MMAS-8) questionnaire in its adapted version for the Spanish population.
View Article and Find Full Text PDFAssociation of Alzheimer's Disease Polygenic Risk Score with Concussion Severity and Recovery Metrics.
Sports Med
January 2025
Indiana Alzheimer's Disease Research Center, Indiana University School of Medicine, Indianapolis, IN, USA.
Background: Identification of genetic alleles associated with both Alzheimer's disease (AD) and concussion severity/recovery could help explain the association between concussion and elevated dementia risk. However, there has been little investigation into whether AD risk genes associate with concussion severity/recovery, and the limited findings are mixed.
Objective: We used AD polygenic risk scores (PRS) and APOE genotypes to investigate any such associations in the NCAA-DoD Grand Alliance CARE Consortium (CARE) dataset.
Trends in female applicants to Canadian ophthalmology residency programs from 1998-2020.
Can Med Educ J
December 2024
Department of Ophthalmology, Ivey Eye Institute, Schulich School of Medicine & Dentistry, Western University, Ontario, Canada.
Background: Ophthalmology has historically been a male-dominated specialty. Despite there being a higher proportion of females in Canadian medical schools since the early 2000s, it is unknown if trends in female applicants and those accepted to ophthalmology have followed suit. This study aims to evaluate trends in gender representation of ophthalmology applicants to Canadian residency programs from 1998 to 2020 and to compare those trends to other surgical specialties.
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