Antimicrobial substances from the rare actinomycete NR4-ASC07.

NR4-ASC07 is a rare actinomycete isolated from soil in Sirindhorn peat swamp forest. The crude extract of its culture broth exhibited antimicrobial and anticancer against diverse human pathogens and cancer cells. The chemical investigation of the crude extract led to the isolation of two new metabolites named nonomuric acid () and 3-hydroxy deoxydaunorubicinol aglycone (), along with two known bioactive compounds [-rhodomycinone () and 7-deoxy-13-dihydrocarminomycinone ()]. Compounds and showed antimalarial activity with the half maximal inhibitory concentration (IC) of 8.00 and 8.88 μg mL, respectively. Compound inhibited growth of and at the minimum inhibitory concentrations of 50.0 and 12.50 μg mL, respectively. Every compound exhibited cytotoxicity against cancer cells tested at IC ≥ 6.34 μg mL. These finding are the first report of bioactive metabolites produced by strain NR4-ASC07, suggesting that rare actinomycetes are yet promising sources for novel drug discovery.