AI Article Synopsis
- Researchers successfully developed a new method for Csp3-Csp2 cross-coupling, utilizing aldehydes as α-alkoxyalkyl anion equivalents.
- The reaction, which is catalyzed by both palladium and copper, combines aromatic aldehydes and aryl bromides with silylboronates to produce silyl-protected benzhydrol derivatives.
- The process involves creating a nucleophilic α-silyloxybenzylcopper(i) species that then undergoes palladium-catalyzed cross-coupling with aryl bromides.
Article Abstract
The first Csp3-Csp2 cross-coupling using aldehydes as latent α-alkoxyalkyl anion equivalents has been achieved. The synergistic palladium/copper-catalyzed reaction of aromatic aldehydes and aryl bromides with a silylboronate afforded the three-component coupling products, silyl-protected benzhydrol derivatives. The reaction pathway involves the catalytic formation of a nucleophilic α-silyloxybenzylcopper(i) species followed by its palladium-catalyzed cross-coupling with aryl bromides.
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| http://dx.doi.org/10.1039/c8cc01055b | DOI Listing |
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Article Synopsis
- Researchers successfully developed a new method for Csp3-Csp2 cross-coupling, utilizing aldehydes as α-alkoxyalkyl anion equivalents.
- The reaction, which is catalyzed by both palladium and copper, combines aromatic aldehydes and aryl bromides with silylboronates to produce silyl-protected benzhydrol derivatives.
- The process involves creating a nucleophilic α-silyloxybenzylcopper(i) species that then undergoes palladium-catalyzed cross-coupling with aryl bromides.
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