Background: There have been no previous reports that apolipoprotein (apo) A-I mimetic peptide improves survival rate after myocardial infarction (MI).
Method And Results: Male C57Bl/6J mice were subjected to left coronary artery permanent ligation as a model of MI. We synthesized a novel 24-amino acid apoA-I mimetic peptide-type5 (FAMP5), which potently removes cholesterol via specific ATP-binding cassette transporter A1 (ABCA1). FAMP5 was associated with a significantly improved survival rate by protecting against cardiac rupture compared to the control. mRNA levels for eNOS, Gata-4, CTGF and ANP were significantly increased in the hearts of the FAMP5-treated group, while that for MCP-1 decreased.
Conclusion: This is the first report that high-density lipoprotein (HDL) therapy with FAMP5 improved the survival rate after MI.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5801440 | PMC |
| http://dx.doi.org/10.1016/j.ijchv.2014.05.005 | DOI Listing |
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