[This corrects the article DOI: 10.1371/journal.pone.0187532.].
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5813979 | PMC |
| http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0192988 | PLOS |
Publication Analysis
Top Keywords
Similar Publications
Microglial double stranded DNA accumulation induced by DNase II deficiency drives neuroinflammation and neurodegeneration.
J Neuroinflammation
January 2025
State Key Laboratory of Biopharmaceutical Preparation and Delivery, Institute of Process Engineering, Chinese Academy of Sciences, Haidian District, Beijing, 100190, China.
Background: Deoxyribonuclease 2 (DNase II) is pivotal in the clearance of cytoplasmic double stranded DNA (dsDNA). Its deficiency incurs DNA accumulation in cytoplasm, which is a hallmark of multiple neurodegenerative diseases. Our previous study showed that neuronal DNase II deficiency drove tau hyperphosphorylation and neurodegeneration (Li et al.
View Article and Find Full Text PDFCapnocytophaga canimorsus in Iliac Artery Mycotic Aneurysm: The Role of Molecular Diagnostics.
Am J Case Rep
January 2025
Vascular and Endovascular Surgery, Department of Cardiovascular Surgery, Mayo Clinic Health System, Eau Claire, WI, USA.
BACKGROUND The bacterial organism Capnocytophaga canimorsus is an oral commensal of cats and dogs and can cause life-threatening infections like mycotic aneurysm, meningitis, and sepsis. Mycotic aneurysms occur when microbial infections cause arterial wall degeneration. Difficulty in diagnosing Capnocytophaga canimorsus infection can occur due to the bacteria's fastidious nature and laboratory testing limitations, contributing to the infection's high morbidity and mortality.
View Article and Find Full Text PDFHymenoptera venom allergy in children.
Ital J Pediatr
December 2024
Department of Health Sciences, University of Florence, Florence, 50139, Italy.
From a taxonomic point of view, Hymenoptera are subclassified into families: Apidae, including honeybees (Apis mellifera) and bumblebees (Bombus), and Vespidae, which, in turn, are divided into the subfamilies of Vespinae (wasps, including hornets, vespules, dolichovespules) and Polistinae (paper wasp). Hypersensitivity to Hymenoptera venom can be linked to immunological (IgE-mediated or non-IgE-mediated) and non-immunological mechanisms. Reactions are classified into local reactions, large local reactions, systemic reactions, toxic reactions, and unusual reactions.
View Article and Find Full Text PDFA supervised machine learning statistical design of experiment approach to modeling the barriers to effective snakebite treatment in Ghana.
PLoS Negl Trop Dis
December 2024
Department of Health Sciences, Brock University, St Catharines, Ontario, Canada.
Article Synopsis
- Snakebite envenoming poses a significant health risk, particularly in tropical regions, affecting 2.5 million people annually and causing up to 138,000 deaths, prompting the WHO to aim for a 50% reduction in related fatalities by 2030.
- A study leveraging MaxDiff statistical design and machine learning analyzed data from 6921 responses, finding that while no individual algorithm was superior, the Generalized Regression Model (Ridge) effectively identified major barriers to treatment, including high costs of antivenoms and limited access in remote areas.
- The research highlights critical obstacles to effective snakebite treatment in Ghana, suggesting that addressing these issues is essential for improving health outcomes and meeting global health goals.
MAM-STAT3-Driven Mitochondrial Ca Upregulation Contributes to Immunosenescence in Type A Mandibuloacral Dysplasia Patients.
Adv Sci (Weinh)
December 2024
Guangdong Key Laboratory of Genomic Stability and Disease Prevention, Shenzhen Key Laboratory of Anti-Aging and Regenerative Medicine, Shenzhen Engineering Laboratory of Regenerative Technologies for Orthopedic Diseases, Department of Medical Cell Biology and Genetics, Health Science Center, Shenzhen University, Shenzhen, 518060, China.
Individuals with homozygous laminA/C p.R527C mutations manifest a severe form of Mandibuloacral dysplasia-(MAD) and exhibit overlapping progeroid symptoms, for which the underlying molecular pathology remains unknown. Herein, it is shown that MAD patients achieved inflammaging with different pro-inflammatory cytokines compared to progeria-(HGPS) patient.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!