Toxicity of PEG-Coated CoFeO Nanoparticles with Treatment Effect of Curcumin.

In this work, CoFeO nanoparticles coated with polyethylene glycol (PEG) were successfully synthesized via a hydrothermal technique. Morphological studies of the samples confirmed the formation of polycrystalline pure-phase PEG-CoFeO nanoparticles with sizes of about 24 nm. Toxicity induced by CoFeO nanoparticles was investigated, and biological assays were performed to check the toxicity effects of CoFeO nanoparticles. Moreover, the healing effect of toxicity induced in living organisms was studied using curcumin and it was found that biochemical indexes detoxified and improved to reach its normal level after curcumin administration. Thus, PEG-coated CoFeO synthesized through a hydrothermal method can be utilized in biomedical applications and curcumin, which is a natural chemical with no side effects, can be used for the treatment of toxicity induced by the nanoparticles in living organisms.