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Comparison of Oropharyngeal Microbiota from Children with Asthma and Cystic Fibrosis. | LitMetric

AI Article Synopsis

  • A study investigated the microbiota in the lungs and throats of healthy children, those with asthma, and those with cystic fibrosis (CF) to understand how oropharyngeal microbiota affects lung health.
  • Results indicated that while all groups shared a core microbiome, children with CF showed significantly lower microbial diversity and increased levels of harmful bacteria compared to healthy controls and asthmatics.
  • The findings suggest that the reduction in microbial diversity and increase in opportunistic pathogens in CF may be linked to impaired immune defense in these children.

Article Abstract

A genuine microbiota resides in the lungs which emanates from the colonization by the oropharyngeal microbiota. Changes in the oropharyngeal microbiota might be the source of dysbiosis observed in the lower airways in patients suffering from asthma or cystic fibrosis (CF). To examine this hypothesis, we compared the throat microbiota from healthy children ( = 62) and that from children with asthma ( = 27) and CF ( = 57) aged 6 to 12 years using 16S rRNA amplicon sequencing. Our results show high levels of similarities between healthy controls and children with asthma and CF revealing the existence of a core microbiome represented by , , , , and . However, in CF, the global diversity, the bacterial load, and abundances of 53 OTUs were significantly reduced, whereas abundances of 6 OTUs representing opportunistic pathogens such as , , and were increased compared to those in healthy controls controls and asthmatics. Our data reveal a core microbiome in the throat of healthy children that persists in asthma and CF indicating shared host regulation favoring growth of commensals. Furthermore, we provide evidence for dysbiosis with a decrease in diversity and biomass associated with the presence of known pathogens consistent with impaired host defense in children with CF.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5763206PMC
http://dx.doi.org/10.1155/2017/5047403DOI Listing

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