ARE-mRNAs are actively degraded with tristetraprolin (TTP) in resting cells while they turn into stable messengers in activated cells. P38 plays a crucial role in stabilizing ARE-mRNA. Here we reveal that P38 activation represses the interaction between TTP and Ago2, thus restraining TTP from being targeted into processing bodies and stabilizing ARE-mRNA.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5896936 | PMC |
| http://dx.doi.org/10.1091/mbc.E17-02-0105 | DOI Listing |
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