A PHP Error was encountered

Severity: Warning

Message: fopen(/var/lib/php/sessions/ci_sessionli6c1iu938j2lg5c7v4hojef78hpad26): Failed to open stream: No space left on device

Filename: drivers/Session_files_driver.php

Line Number: 177

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once

A PHP Error was encountered

Severity: Warning

Message: session_start(): Failed to read session data: user (path: /var/lib/php/sessions)

Filename: Session/Session.php

Line Number: 137

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once

A PHP Error was encountered

Severity: Warning

Message: file_get_contents(https://...@gmail.com&api_key=61f08fa0b96a73de8c900d749fcb997acc09): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests

Filename: helpers/my_audit_helper.php

Line Number: 143

Backtrace:

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 143
Function: file_get_contents

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 209
Function: simplexml_load_file_from_url

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 994
Function: getPubMedXML

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 3134
Function: GetPubMedArticleOutput_2016

File: /var/www/html/application/controllers/Detail.php
Line: 574
Function: pubMedSearch_Global

File: /var/www/html/application/controllers/Detail.php
Line: 488
Function: pubMedGetRelatedKeyword

File: /var/www/html/index.php
Line: 316
Function: require_once

Aspirin alone and combined with a statin suppresses eicosanoid formation in human colon tissue. | LitMetric

Aspirin alone and combined with a statin suppresses eicosanoid formation in human colon tissue.

J Lipid Res

Medical Department, Division of Gastroenterology, Oncology, Hematology, Rheumatology, and Diabetes, Ruppiner Kliniken, Brandenburg Medical School, Neuruppin, Germany

Published: May 2018

AI Article Synopsis

  • Eicosanoids, like prostaglandins and thromboxanes, are lipids that may promote colon cancer through inflammation, while acetylsalicylic acid (ASA) is linked to a reduced risk of colorectal cancer (CRC) by inhibiting these lipids.
  • A study showed that patients on ASA had significantly lower levels of certain eicosanoids in their colon tissue compared to those not on the drug, suggesting ASA's effectiveness in altering lipid profiles.
  • Interestingly, statin users had higher levels of these eicosanoids, but those taking both ASA and statins exhibited even greater suppression of eicosanoids, indicating potential combined benefits that warrant further investigation for CRC prevention.

Article Abstract

Eicosanoids, including prostaglandins (PGs) and thromboxanes, are broadly bioactive lipid mediators and increase colon tumorigenesis possibly through chronic inflammatory mechanisms. Epidemiological and experimental data suggest that acetylsalicylic acid (ASA) helps prevent colorectal cancer (CRC), possibly through cyclooxygenase (COX)-mediated suppression of eicosanoid, particularly PGE, formation. Recent studies suggest that statins prevent CRC and improve survival after diagnosis. We identified patients on ASA and/or statin treatment undergoing routine colonoscopy and measured eicosanoid levels in colonic mucosa with targeted metabolomics technology (LC-MS/MS). ASA-treated individuals (n = 27) had significantly lower tissue eicosanoid levels of most COX-derived metabolites than untreated individuals (n = 31). In contrast, COX-derived lipid metabolites tended to be higher in patients with statin treatment (n = 7) as compared with those not receiving statins (n = 24). This effect was not discernible in subjects treated with ASA and statins (n = 11): Individuals treated with both drugs showed a pronounced suppression of COX-derived eicosanoids in colon tissue, even compared with subjects treated with ASA alone. Our data from a routine clinical setting support the hypothesis that ASA and statins could inhibit CRC development via lipid mediator modification. Further studies should directly investigate the effect of dual ASA and statin treatment on colon tumorigenesis in humans.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5928440PMC
http://dx.doi.org/10.1194/jlr.M078725DOI Listing

Publication Analysis

Top Keywords

statin treatment
12
colon tissue
8
colon tumorigenesis
8
eicosanoid levels
8
subjects treated
8
treated asa
8
asa statins
8
asa
6
aspirin combined
4
statin
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!