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Plasmacytoid pre-dendritic cells (pDC): from molecular pathways to function and disease association. | LitMetric

Plasmacytoid pre-dendritic cells (pDC): from molecular pathways to function and disease association.

Semin Cell Dev Biol

Institut Curie, PSL Research University, Institut National de la Santé et de la Recherche Médicale (INSERM), U932, F-75005 Paris, France. Electronic address:

Published: February 2019

AI Article Synopsis

Article Abstract

Plasmacytoid pre-dendritic cells (pDC) are a specialized DC population with a great potential to produce large amounts of type I interferon (IFN). pDC are involved in the initiation of antiviral immune responses through their interaction with innate and adaptive immune cell populations. In a context-dependent manner, pDC activation can induce their differentiation into mature DC able to induce both T cell activation or tolerance. In this review, we described pDC functions during immune responses and their implication in the clearance or pathogenicity of human diseases during infection, autoimmunity, allergy and cancer. We discuss recent advances in the field of pDC biology and their implication for future studies.

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Source
http://dx.doi.org/10.1016/j.semcdb.2018.02.014DOI Listing

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