In this article we report recent interesting diagnostic and therapeutic advances in a diverse range of movement disorders with associated psychiatric comorbidity. Areas discussed include social cognition in Huntington disease, neuroimaging of functional movement disorders, treatment of psychosis in Parkinson disease, new advances in autoimmune disease, and management of Tourette syndrome.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5764446 | PMC |
http://dx.doi.org/10.1212/CPJ.0000000000000113 | DOI Listing |
Sci Rep
January 2025
Faculty of Medicine, Department of Neurology, Kırşehir Ahi Evran University, Kırşehir, Turkey.
The Ottawa Sitting Scale is a tool for the multidimensional assessment of sitting balance. This study aimed to investigate the validity, reliability, and psychometric properties of the Turkish version of the Ottawa Sitting Scale (OSS-TR) in Turkish-speaking patients with Parkinson's disease (PD). The study included 56 patients diagnosed with PD based on the UK Brain Bank Criteria.
View Article and Find Full Text PDFGen Hosp Psychiatry
January 2025
Stanley Aronson Chair in Neurodegenerative Disorders, Director, Movement Disorders Program, Butler Hospital, Professor, Department of Neurology, Alpert Medical School of Brown University. Electronic address:
Artif Intell Med
January 2025
Department of Electronics, Information and Bioengineering, Politecnico di Milano, Milan, Italy; Department of Neurosciences and Mental Health, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
The heterogeneity of psychiatric disorders makes researching disorder-specific neurobiological markers an ill-posed problem. Here, we face the need for disease stratification models by presenting a generalizable multivariate normative modelling framework for characterizing brain morphology, applied to bipolar disorder (BD). We used deep autoencoders in an anomaly detection framework, combined for the first time with a confounder removal step that integrates training and external validation.
View Article and Find Full Text PDFParkinsonism Relat Disord
January 2025
Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX, USA; Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA. Electronic address:
Introduction: Assessing the severity of kinetic tremor is important in clinical and research settings. Archimedes spirals are often used to assess tremor severity. Rating tremor from spirals has been based solely on visual information.
View Article and Find Full Text PDFSci Signal
January 2025
Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA.
Chronic exposure to manganese (Mn) induces manganism and has been widely implicated as a contributing environmental factor to Parkinson's disease (PD), featuring notable overlaps between the two in motor symptoms and clinical hallmarks. Here, we developed an adult model of Mn toxicity that recapitulated key parkinsonian features, spanning behavioral deficits, neuronal loss, and dysfunctions in lysosomes and mitochondria. Metabolomics analysis of the brain and body tissues of these flies at an early stage of toxicity identified systemic changes in the metabolism of biotin (also known as vitamin B) in Mn-treated groups.
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