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Cohort profile: Multicenter Networks for Ideal Outcomes of Rare Pediatric Endocrine and Metabolic Diseases in Korea (OUTSPREAD study).
Ann Pediatr Endocrinol Metab
December 2024
Department of Pediatrics, Seoul National University Children's Hospital, Seoul, Korea.
Rare endocrine diseases are complex conditions that require lifelong specialized care due to their chronic nature and associated long-term complications. In Korea, a lack of nationwide data on clinical practice and outcomes has limited progress in patient care. Therefore, the Multicenter Networks for Ideal Outcomes of Pediatric Rare Endocrine and Metabolic Disease (OUTSPREAD) study was initiated.
View Article and Find Full Text PDFGenetic association of type 2 diabetes mellitus and glycaemic factors with primary tumours of the central nervous system.
BMC Neurol
November 2024
Department of Neurosurgery, The First Hospital of Jilin University, Changchun, People's Republic of China.
Article Synopsis
- Type 2 diabetes mellitus (T2DM) is a chronic disease that is becoming more common, and recent studies link it to the occurrence of certain central nervous system (CNS) tumours.
- This research used genetic data to examine how T2DM and related factors, like glucose levels, influence the risk of these tumours, finding significant associations with glioblastoma and several spinal cord tumours.
- The findings enhance our understanding of the relationship between diabetes and CNS tumours, which could lead to improved diagnosis and treatment options in the future.
Central diabetes insipidus: A rare primary manifestation of small-cell lung carcinoma.
J Family Med Prim Care
September 2024
Department of General Medicine, Bangalore Medical College and Research Institute (BMCRI), Bengaluru, Karnataka, India.
Article Synopsis
- - Diabetes insipidus (DI) is linked to abnormal water balance, leading to excessive urination and thirst, with Central DI often caused by factors like autoimmune issues or tumors affecting the brain.
- - A unique case involved a 56-year-old male with small-cell lung carcinoma, initially presenting with symptoms of DI and skin swellings, but the primary lung cancer was undetected at first.
- - Diagnostic tests, including imaging and fine needle aspiration, eventually revealed advanced lung cancer with brain metastases, confirming the link between DI symptoms and the underlying malignancy, prompting palliative care.
Unusual Presentation of Craniopharyngioma Pituitary Mass in a 71-Year-Old Female: A Case Report.
Case Rep Endocrinol
October 2024
Department of Research, Alabama College of Osteopathic Medicine, Dothan, Alabama, USA.
Article Synopsis
- A 71-year-old African-American woman presented with 2 months of headaches and blurred vision, leading to a series of medical evaluations.
- Initially, her conditions seemed undetectable until imaging revealed a mass, resulting in a biopsy that diagnosed her with a craniopharyngioma (WHO grade I).
- The case highlights the importance of recognizing unusual symptoms related to brain tumors and emphasizes the need for targeted diagnosis, treatment, and enhanced patient management strategies for better outcomes.
Post-craniopharyngioma surgery hypocalcemia due to denosumab use for osteoporosis: A case report.
Medicine (Baltimore)
September 2024
Department of Pharmacy, Yichang Central People's Hospital, Yichang, Hubei, China.
Article Synopsis
- Denosumab is a monoclonal antibody used to treat osteoporosis, but it's mostly linked to hypocalcemia in dialysis patients with chronic kidney disease, not after craniopharyngioma surgery.
- A 65-year-old male experienced hypocalcemia shortly after receiving denosumab for osteoporosis post-surgery and had a second episode six months later.
- Managing his hypocalcemia involved intravenous calcium gluconate and oral calcium supplements, highlighting the need for careful monitoring and evaluation of patients receiving denosumab, especially those at higher risk.
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